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AGN » Topics » Allergans use of the LD 50 test warrants attention from management and shareholders for several reasons:

This excerpt taken from the AGN DEF 14A filed Mar 19, 2009.

Allergan’s use of the LD50 test warrants attention from management and shareholders for several reasons:

 

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Causing animals to suffer for the sake of testing a cosmetic product (i.e. Botox Cosmetic) is widely perceived as unethical.

 

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Allergan is relying on a test that was developed in 1927, is considered outdated and crude, and has been all but abandoned by the safety testing community.

 

 

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Although the LD50 test is the standard for the narrow application of assessing the potency of botulinum toxin products, Allergan is particularly vulnerable to public criticism because it is the only company currently licensed to sell such products for cosmetic purposes in the U.S.

 

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The testing controversy concerns Botox and Botox Cosmetic, which accounted for over 31% of Allergan’s net sales in 2007.

 

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A Botox-like competitive product manufactured with a non-animal alternative test would have a strong marketing advantage in the U.S. and the European Union.

Given the seriousness of the issue, Allergan should protect the Company and its shareholders by providing updates on its efforts to replace the LD50 test. The National Research Council forecasts that, within a generation, new methods will greatly reduce, if not eliminate, all animal testing. Eliminating LD50 testing should be a priority in this process.

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