Annual Reports

 
Other

  • 6-K (Mar 12, 2018)
  • 6-K (Mar 7, 2018)
  • IRANNOTICE (Mar 6, 2018)
  • 6-K (Mar 1, 2018)
  • 6-K (Feb 23, 2018)
  • 6-K (Feb 20, 2018)
AstraZeneca 6-K 2012

Documents found in this filing:

  1. 6-K
  2. 6-K
 
FORM 6-K
 
 
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
 
 
Report of Foreign Issuer
 
 
Pursuant to Rule 13a-16 or 15d-16 of
the Securities Exchange Act of 1934
 
For April 2012
 
Commission File Number:  001-11960
 
AstraZeneca PLC
 
2 Kingdom Street, London W2 6BD
 
Indicate by check mark whether the registrant files or will file annual reports under cover of Form 20-F or Form 40-F.
 
Form 20-F X            Form 40-F  __
 
Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(1):            
 
Indicate by check mark if the registrant is submitting the Form 6-K in paper as permitted by Regulation S-T Rule 101(b)(7): ______
 
Indicate by check mark whether the registrant by furnishing the information contained in this Form is also thereby furnishing the information to the Commission pursuant to Rule 12g3-2(b) under the Securities Exchange Act of 1934.
 
Yes  __                 No X
 
If “Yes” is marked, indicate below the file number assigned to the Registrant in connection with Rule 12g3-2(b):   82-_____________
 
 
 

 

 
AstraZeneca PLC

INDEX TO EXHIBITS

1.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 2 April 2012.

2.
Press release entitled, “Transparency Directive Voting Rights and Capital”, dated 2 April 2012.

3.
Press release entitled, “Transaction by Person Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4”, dated 2 April 2012.

4.
Press release entitled, “Transaction by Person Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4”, dated 2 April 2012.

5.
Press release entitled, “Transaction by Persons Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4”, dated 2 April 2012.

6.
Press release entitled, “Transaction by Person Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4”, dated 2 April 2012.

7.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 3 April 2012.

8.
Press release entitled, “AstraZeneca and Amgen announce collaboration to jointly develop and commercialise clinical-stage inflammation portfolio”, dated 3 April 2012.

9.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 4 April 2012.

10.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 5 April 2012.

11.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 10 April 2012.

12.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 11 April 2012.

13.
Press release entitled, “Annual Information Update”, dated 11 April 2012.

14.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 12 April 2012.

 
 

 
 
15.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 13 April 2012.

16.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 16 April 2012.

17.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 17 April 2012.

18.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 18 April 2012.

19.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 19 April 2012.

20.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 20 April 2012.

21.
Press release entitled, “Forxiga (dapagliflozin) receives positive CHMP opinion in the European Union for the treatment of type 2 diabetes”, dated 20 April 2012.

22.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 23 April 2012.

23.
Press release entitled, “AstraZeneca to Acquire Ardea Biosciences for $1 Billion (net of existing cash) including lead product lesinurad in Phase III development for gout”, dated 23 April 2012.

24.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 24 April 2012.

25.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 25 April 2012.

26.
Press release entitled, “AstraZeneca PLC Notice of Results”, dated 25 April 2012.

27.
Press release entitled, “AstraZeneca PLC First Quarter Results 2012”, dated 26 April 2012.

28.
Press release entitled, “David Brennan to retire as AstraZeneca’s Chief Executive Officer”, dated 26 April 2012.

 
3

 
 
29.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 26 April 2012.

30.
Press release entitled, “AstraZeneca PLC Annual General Meeting, dated 26 April 2012.

31.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 27 April 2012.

32.
Press release entitled, “Transactions by Persons Discharging Managerial Responsibilities Disclosure Rule DTR 3.1.4”, dated 27 April 2012.

33.
Press release entitled, “Repurchase of shares in AstraZeneca PLC”, dated 30 April 2012.
 
 
4

 
 
 
SIGNATURES
 
 
Pursuant to the requirements of the Securities Exchange Act of 1934, the Registrant has duly caused this report to be signed on its behalf by the undersigned, thereunto duly authorized.
 

  AstraZeneca PLC  
         
         
Date: 10 May 2012
By:
    /s/ Claire-Marie OGrady
 
  Name:
Claire-Marie OGrady
 
  Title:
Deputy Company Secretary
 
 

 
5

 

Item 1

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 305,437 ordinary shares of AstraZeneca PLC at a price of 2785 pence per share on 30 March 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,493,566.


A C N Kemp
Company Secretary
2 April 2012
 
 
 

 
 
Item 2
 

 
Transparency Directive
 
Voting Rights and Capital

The following notification is made in accordance with the UK Financial Services Authority Disclosure and Transparency Rule 5.6.1.  On 31 March 2012 the issued share capital of AstraZeneca PLC with voting rights is 1,273,930,953 ordinary shares of US$0.25.  No shares are held in Treasury.  Therefore, the total number of voting rights in AstraZeneca PLC is 1,273,930,953.

The above figure for the total number of voting rights may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, AstraZeneca PLC under the Financial Services Authority's Disclosure and Transparency Rules.


A C N Kemp
Company Secretary
2 April 2012
 
 
 

 

Item 3

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

The interest of David Brennan, a Director of the Company, in AstraZeneca PLC ordinary shares, has changed as detailed below.

On 30 March 2012, Mr Brennan was granted awards under the terms of the AstraZeneca Investment Plan (AZIP) and the AstraZeneca Performance Share Plan (AZPSP) over the Company’s ordinary shares.  A summary of these plans can be found in the AstraZeneca Annual Report and Form 20-F Information 2011 which is available on the Company’s website www.astrazeneca.com.
 
 
Name
Shares awarded
under AZIP
Shares awarded
under AZPSP
Award price
per share
David Brennan
22,219
133,318
2805p

The AZIP award is subject to a four-year performance period (1 January 2012 to 31 December 2015) and a subsequent four-year holding period (1 January 2016 to 31 December 2019). The performance hurdle that applies to the AZIP award relates to dividends and dividend cover.

The AZPSP award is subject to a three-year performance period (1 January 2012 to 31 December 2014). The performance measures that apply to the AZPSP award relate to relative total shareholder return and cash flow.

Mr Brennan has interests in both the ordinary shares and the American Depositary Shares (ADSs) of AstraZeneca PLC.  One ADS equals one ordinary share.

As a result of these transactions, Mr Brennan has an interest in 734,270 ordinary shares and 83,344 AstraZeneca ADSs, which together represent approximately 0.06% of the Company’s issued ordinary capital.

A C N Kemp
Company Secretary
2 April 2012
 
 
 

 

Item 4

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

The interest of Simon Lowth, a Director of the Company, in AstraZeneca PLC ordinary shares, has changed as detailed below.

On 30 March 2012, Mr Lowth was granted awards under the terms of the AstraZeneca Investment Plan (AZIP) and the AstraZeneca Performance Share Plan (AZPSP) over the Company’s ordinary shares.  A summary of these plans can be found in the AstraZeneca Annual Report and Form 20-F Information 2011 which is available on the Company’s website www.astrazeneca.com.
 
 
Name
Shares awarded
under AZIP
Shares awarded
under AZPSP
Award price
per share
Simon Lowth
11,764
70,588
2805p

The AZIP award is subject to a four-year performance period (1 January 2012 to 31 December 2015) and a subsequent four-year holding period (1 January 2016 to 31 December 2019). The performance hurdle that applies to the AZIP award relates to dividends and dividend cover.

The AZPSP award is subject to a three-year performance period (1 January 2012 to 31 December 2014). The performance measures that apply to the AZPSP award relate to relative total shareholder return and cash flow.

As a result of these awards, Mr Lowth has an interest in 291,399 ordinary shares which represents approximately 0.02% of the Company’s issued ordinary capital.

A C N Kemp
Company Secretary
2 April 2012
 
 
 

 

Item 5

Transactions by Persons Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

On 30 March 2012, the following individuals, who are all persons discharging managerial responsibilities, were each granted awards under the terms of the AstraZeneca Investment Plan (AZIP) and the AstraZeneca Performance Share Plan (AZPSP) over the Company’s ordinary shares, or, in the case of David Smith, Lynn Tetrault and Tony Zook, over the Company’s American Depositary Shares (ADSs).  One ADS equals one ordinary share.  A summary of these plans can be found in the AstraZeneca Annual Report and Form 20-F Information 2011 which is available on the Company’s website www.astrazeneca.com.

 
Name
Shares awarded
under AZIP
Shares awarded
under AZPSP
Award price
per share
Katarina Ageborg
3,291
19,747
2805p
Martin Mackay
16,764
100,588
2805p
Jeff Pott
8,975
53,850
2805p
David Smith
8,306
49,841
$44.82
Lynn Tetrault
7,194
43,168
$44.82
Tony Zook
16,669
100,014
$44.82

The AZIP award is subject to a four-year performance period (1 January 2012 to 31 December 2015) and a subsequent four-year holding period (1 January 2016 to 31 December 2019). The performance hurdle that applies to the AZIP award relates to dividends and dividend cover.

The AZPSP award is subject to a three-year performance period (1 January 2012 to 31 December 2014). The performance measures that apply to the AZPSP award relate to relative total shareholder return and cash flow.


A C N Kemp
Company Secretary
2 April 2012

 
 

 

Item 6

Transaction by Person Discharging Managerial Responsibilities
Disclosure Rule DTR 3.1.4

The interest of Lynn Tetrault, a person discharging managerial responsibility, in the shares of AstraZeneca PLC has changed as detailed below.  Lynn Tetrault has interests in the American Depositary Shares (ADSs) of AstraZeneca PLC.  One ADS equals one ordinary share.

On 30 March 2012, Mrs Tetrault exercised an option over 73,926 ADSs at an option price of $33.39 per ADS.

Following the exercise, Mrs Tetrault sold 63,516 of the 73,926 ADSs so acquired at a price of $44.52 per ADS.

On 30 March 2012, Mrs Tetrault also sold 12,868 ADSs at a price of $44.68 per ADS.


A C N Kemp
Company Secretary
2 April 2012
 
 
 

 

Item 7

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 303,743 ordinary shares of AstraZeneca PLC at a price of 2801 pence per share on 2 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,627,210.


A C N Kemp
Company Secretary
3 April 2012

 
 

 

ITEM 8

ASTRAZENECA AND AMGEN ANNOUNCE COLLABORATION TO JOINTLY
DEVELOP AND COMMERCIALISE CLINICAL-STAGE INFLAMMATION PORTFOLIO

Collaboration Comprises Five Monoclonal Antibodies
Brodalumab (AMG 827) Phase 3 Trial Planned in 2012


AstraZeneca and Amgen today announced an agreement to jointly develop and commercialise five monoclonal antibodies from Amgen’s clinical inflammation portfolio: AMG 139, AMG 157, AMG 181, AMG 557 and brodalumab (AMG 827).

The companies believe all the molecules have novel profiles and offer the potential to deliver important treatments across multiple indications in inflammatory diseases. The collaboration will provide Amgen with additional resources to optimally progress its portfolio, and Amgen will benefit from the strong respiratory, inflammation and asthma development expertise of MedImmune, AstraZeneca’s biologics arm. The collaboration will also capitalise on AstraZeneca’s global commercial reach in respiratory and gastrointestinal diseases. The agreement does not include certain territories previously partnered by Amgen for brodalumab with Kyowa Hakko Kirin and AMG 557 with Takeda.

Under the terms of the agreement, AstraZeneca will make a one-time $50 million upfront payment and the companies will share both costs and profits.  Based on current plans, approximately 65 percent of costs for the 2012-2014 period will be funded by AstraZeneca. Thereafter, the companies will split costs equally. Amgen will book sales globally and will retain a low single-digit royalty for brodalumab and a mid single-digit royalty for the rest of the portfolio after which the companies will share profits equally.

AstraZeneca will lead the development and commercialisation strategy of AMG 139, AMG 157 and AMG 181, while Amgen will lead the development and commercialisation strategy of brodalumab and AMG 557. Each development and commercialisation lead will be under the oversight of joint governing bodies. For brodalumab, commercial promotion will be split. Amgen will promote in dermatology indications in the US and Canada, and in rheumatology indications in US, Canada and Europe. AstraZeneca will promote in respiratory and, initially, in dermatology indications of brodalumab across all territories outside of the US, Canada and those markets where Amgen has existing partnerships.  Allocation of promotion rights for other territories, indications and molecules will be agreed later between the companies.

“We are delighted to join forces with Amgen in developing and commercialising these novel clinical-stage assets that add value to our pipeline and build on our expertise in biologics. This creative collaboration will make the most of both companies’ respective capabilities, including AstraZeneca’s extensive global reach, to help bring these potentially innovative treatment options for a variety of respiratory and inflammatory diseases to patients around the world,” said David Brennan, Chief Executive Officer, AstraZeneca.

“We are very excited at the prospect of collaborating with a well-respected organisation like AstraZeneca to advance our inflammation pipeline,” said Kevin Sharer, Chairman and CEO at Amgen. “We believe this collaboration has the potential to bring more therapies to patients sooner, across more geographic areas. We are impressed with AstraZeneca’s extensive experience in developing and launching products in the respiratory and gastroenterology areas, and believe this collaboration is an opportunity to work with a partner that has leading regulatory and commercial expertise in inflammation indications.”
 
 
 

 

About the inflammation portfolio included in the agreement
 
Under the agreement, the companies will jointly develop and commercialise the following five monoclonal antibodies (immunoglobin proteins that have been synthesized using recombinant DNA technology) from Amgen’s clinical-stage portfolio:

·  
Brodalumab (AMG 827) is a human monoclonal antibody that binds to and blocks signaling via the IL-17 receptor. Brodalumab is currently being investigated for the treatment of psoriasis (completed Phase 2 and planned Phase 3), psoriatic arthritis (Phase 2) and asthma (Phase 2).
·  
AMG 139 is a human monoclonal antibody that neutralises IL-23 interaction with its receptor while sparing IL-12. It is being investigated as a treatment for a variety of inflammatory disorders. AMG 139 is being investigated in Phase 1 for Crohn’s disease, with lifecycle possibilities in psoriasis and other inflammatory conditions.
·  
AMG 181 is a human monoclonal antibody to alpha4/beta7 that blocks binding to MAdCAM-1. It is being investigated in Phase 1b trials for the treatment of ulcerative colitis and Crohn's disease.
·  
AMG 557 is a human monoclonal antibody that binds to B7 related protein (B7RP-1). It is being investigated in Phase 1b for its utility in autoimmune diseases such as systemic lupus erythematosus.
·  
AMG 157 is a human monoclonal antibody that blocks the interaction of thymic stromal lymphopoietin (TSLP) with the TSLP receptor. AMG 157 is being investigated in Phase 1b trials for its potential as a treatment for asthma.

About Amgen
 
Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science’s promise by bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid arthritis, bone disease, and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people’s lives. To learn more about our pioneering science and our vital medicines, visit www.amgen.com. Follow us on www.twitter.com/amgen.

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialization of prescription medicines for gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com.>

AstraZeneca:
Media Enquiries
Sarah Lindgreen
+44 20 7604 8033
 
Esra Erkal-Paler
+44 20 7604 8030
 
     
Investor Enquiries UK
   
James Ward-Lilley
+44 20 7604 8122
mob: +44 7785 432613
Karl Hård
+44 20 7604 8123
mob: +44 7789 654364
Nicklas Westerholm
+44 20 7604 8124
mob: +44 7585 404950
     
Investor Enquiries US
   
Ed Seage
+1 302 886 4065
mob: +1 302 373 1361
Jorgen Winroth
+1 212 579 0506
mob: +1 917 612 4043
     
Amgen:
   
Media Enquiries
   
Christine Regan
+1 805-447-5476
 
     
Investor Enquiries
   
Arvind Sood
+1 805-447-1060
 
 
3 April 2012

- ENDS  -
 
 
Page> 2/2

 

Item 9

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 299,928 ordinary shares of AstraZeneca PLC at a price of 2838 pence per share on 3 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,618,531.


A C N Kemp
Company Secretary
4 April 2012

 
 

 

Item 10

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 303,195 ordinary shares of AstraZeneca PLC at a price of 2807 pence per share on 4 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,444,803.


A C N Kemp
Company Secretary
5 April 2012
 
 
 

 

Item 11

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 306,488 ordinary shares of AstraZeneca PLC at a price of 2776 pence per share on 5 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,273,171,200.


A C N Kemp
Company Secretary
10 April 2012

 
 

 

Item 12

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 305,177 ordinary shares of AstraZeneca PLC at a price of 2788 pence per share on 10 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,272,934,176.


A C N Kemp
Company Secretary
11 April 2012

 
 

 

Item 13

ASTRAZENECA PLC
ANNUAL INFORMATION UPDATE

As required under the Prospectus (Directive 2003/71/EC) Regulations 2005 and paragraph 5.2 of the Prospectus Rules, and following publication of the Annual Report and Form 20-F Information on 26 March 2012, AstraZeneca PLC is presenting its Annual Information Update in relation to information that has been published or made available to the public between 08 April 2011 and 10 April 2012.

This Annual Information Update is also being made available on the Investors section of our website, www.astrazeneca.com.

The information referred to in this Annual Information Update was correct at the time it was published but may now be out of date.

1.
Announcements made via a RIS

The documents listed below were published via a Regulatory Information Service on or around the dates indicated.

Date
Description of Contents of Announcement
08/04/11
Transaction in Own Shares
08/04/11
Annual Information Update
11/04/11
Transaction in Own Shares
12/04/11
Transaction in Own Shares
13/04/11
Transaction in Own Shares
14/04/11
Transaction in Own Shares
15/04/11
Transaction in Own Shares
18/04/11
Transaction in Own Shares
19/04/11
Transaction in Own Shares
20/04/11
Transaction in Own Shares
21/04/11
Transaction in Own Shares
26/04/11
Transaction in Own Shares
27/04/11
Transaction in Own Shares
27/04/11
Notice of Results
28/04/11
Transaction in Own Shares
28/04/11
1st Quarter Results (part 1 of 2)
28/04/11
1st Quarter Results (part 2 of 2)
28/04/11
Result of Meeting
28/04/11
Filing of Annual Report on SEC
03/05/11
03/05/11
04/05/11
04/05/11
04/05/11
Transaction in Own Shares
Total Voting Rights
Transaction in Own Shares
Director/PDMR Shareholding
Director/PDMR Shareholding
 
 
 

 
 
05/05/11
06/05/11
06/05/11
06/05/11
10/05/11
11/05/11
12/05/11
13/05/11
16/05/11
17/05/11
18/05/11
19/05/11
20/05/11
23/05/11
24/05/11
24/05/11
25/05/11
26/05/11
27/05/11
31/05/11
01/06/11
01/06/11
01/06/11
Transaction in Own Shares
Transaction in Own Shares
Share Repurchase Programme
Director/PDMR Shareholding
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Director/PDMR Shareholding
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Health Canada approves Brilinta
Total Voting Rights
02/06/11
03/06/11
06/06/11
07/06/11
08/06/11
09/06/11
10/06/11
13/06/11
14/06/11
15/06/11
15/06/11
16/06/11
17/06/11
20/06/11
21/06/11
22/06/11
22/06/11
23/06/11
24/06/11
27/06/11
27/06/11
28/06/11
29/06/11
30/06/11
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Director/PDMR Shareholding
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Sells Astra Tech to Dentsply International
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Announces Phase3 study with BMS on Dapagliflozin
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
01/07/11
Transaction in Own Shares
01/07/11
Nexium gets first approval in Japan
01/07/11
Total Voting Rights
 
 
 

 
 
04/07/11
Transaction in Own Shares
05/07/11
Transaction in Own Shares
06/07/11
Transaction in Own Shares
07/07/11
Transaction in Own Shares
08/07/11
Transaction in Own Shares
11/07/11
Transaction in Own Shares
12/07/11
Transaction in Own Shares
13/07/11
Transaction in Own Shares
14/07/11
Transaction in Own Shares
15/07/11
Transaction in Own Shares
18/07/11
Transaction in Own Shares
19/07/11
Transaction in Own Shares
20/07/11
Transaction in Own Shares
20/07/11
FDA advisors make recommendation on Dapagliflozin
21/07/11
Transaction in Own Shares
21/07/11
22/07/11
25/07/11
26/07/11
27/07/11
27/07/11
28/07/11
28/07/11
28/07/11
28/07/11
29/07/11
FDA approves Brilinta for us in the US
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Notice of Results
Transaction in Own Shares
Second Quarter Results 2011 – Part 1 of 3
Second Quarter Results 2011 – Part 2 of 3
Second Quarter Results 2011 – Part 3 of 3
Transaction in Own Shares
01/08/11
Transaction in Own Shares
01/08/11
Total Voting Rights
02/08/11
03/08/11
04/08/11
05/08/11
08/08/11
09/08/11
10/08/11
10/08/11
11/08/11
12/08/11
12/08/11
15/08/11
17/08/11
18/08/11
19/08/11
22/08/11
23/08/11
24/08/11
24/08/11
25/08/11
26/08/11
26/08/11
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Director/PDMR Shareholding
Transaction in Own Shares
Transaction in Own Shares
Director/PDMR Shareholding
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Block Listing Application
Transaction in Own Shares
Transaction in Own Shares
Share Repurchase Programme
 
 
 

 
 
30/08/11
30/08/11
31/08/11
31/08/11
31/08/11
01/09/11
01/09/11
02/09/11
02/09/11
05/09/11
06/09/11
07/09/11
08/09/11
09/09/11
12/09/11
13/09/11
13/09/11
13/09/11
Transaction in Own Shares
Director/PDMR Shareholding
Transaction in Own Shares
Sale of AstraTech to DENTSPLY complete
Director/PDMR Shareholding
Transaction in Own Shares
Total Voting Rights
Transaction in Own Shares
Top-Line Results from SATURN study
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Transaction in Own Shares
Block Listing Application
Block Listing Six Month Interim Review
14/09/11
Transaction in Own Shares
15/09/11
Transaction in Own Shares
16/09/11
Transaction in Own Shares
19/09/11
Transaction in Own Shares
20/09/11
Transaction in Own Shares
21/09/11
Transaction in Own Shares
22/09/11
Transaction in Own Shares
23/09/11
Transaction in Own Shares
23/09/11
Komboglyze receives positive CHMP opinion
26/09/11
Transaction in Own Shares
27/09/11
Transaction in Own Shares
28/09/11
Transaction in Own Shares
29/09/11
Transaction in Own Shares
30/09/11
Transaction in Own Shares
30/09/11
US Seroquel XR Patent Litigation
30/09/11
Share Repurchase Programme
03/10/11
Transaction in Own Shares
03/10/11
Total Voting Rights
04/10/11
Transaction in Own Shares
05/10/11
Transaction in Own Shares
05/10/11
Settles with Accord and Intas over Seroquel XR
06/10/11
Transaction in Own Shares
07/10/11
Transaction in Own Shares
10/10/11
Transaction in Own Shares
11/10/11
Transaction in Own Shares
12/10/11
Transaction in Own Shares
13/10/11
Transaction in Own Shares
14/10/11
Transaction in Own Shares
17/10/11
Transaction in Own Shares
18/10/11
Transaction in Own Shares
19/10/11
Transaction in Own Shares
20/10/11
Transaction in Own Shares
 
 
 

 
 
21/10/11
Transaction in Own Shares
24/10/11
Transaction in Own Shares
25/10/11
Transaction in Own Shares
26/10/11
Transaction in Own Shares
26/10/11
Notice of Results
27/10/11
Transaction in Own Shares
27/10/11
3rd Quarter Results – Part 1 of 2
27/10/11
3rd Quarter Results – Part 2 of 2
27/10/11
FDA extends Dapa action date by three months
28/10/11
Transaction in Own Shares
28/10/11
Director/PDMR Shareholding
31/10/11
Transaction in Own Shares
01/11/11
Transaction in Own Shares
01/11/11
Total Voting Rights
02/11/11
Transaction in Own Shares
03/11/11
Transaction in Own Shares
04/11/11
Transaction in Own Shares
07/11/11
Transaction in Own Shares
08/11/11
Transaction in Own Shares
08/11/11
First top line results for TC-5214 with Targacept
09/11/11
Transaction in Own Shares
10/11/11
Transaction in Own Shares
11/11/11
Transaction in Own Shares
14/11/11
Transaction in Own Shares
15/11/11
Transaction in Own Shares
16/11/11
Transaction in Own Shares
17/11/11
Transaction in Own Shares
18/11/11
Transaction in Own Shares
21/11/11
Transaction in Own Shares
22/11/11
Transaction in Own Shares
23/11/11
Transaction in Own Shares
24/11/11
Transaction in Own Shares
25/11/11
Transaction in Own Shares
28/11/11
Transaction in Own Shares
29/11/11
Transaction in Own Shares
29/11/11
Komboglyze gets EU marketing authorisation
30/11/11
Transaction in Own Shares
01/12/11
Transaction in Own Shares
01/12/11
Total Voting Rights
01/12/11
Blocklisting Interim Review
02/12/11
Transaction in Own Shares
05/12/11
Transaction in Own Shares
06/12/11
Transaction in Own Shares
07/12/11
Transaction in Own Shares
08/12/11
Transaction in Own Shares
08/12/11
AstraZeneca streamlines US sales organisation
09/12/11
Transaction in Own Shares
12/12/11
Transaction in Own Shares
13/12/11
Transaction in Own Shares
14/12/11
Transaction in Own Shares
 
 
 

 
 
15/12/11
Transaction in Own Shares
15/12/11
Share Repurchase Programme
16/12/11
Transaction in Own Shares
19/12/11
Transaction in Own Shares
20/12/11
Transaction in Own Shares
20/12/11
Updates on Olaparib and TC-5214 programmes
21/12/11
Transaction in Own Shares
22/12/11
Transaction in Own Shares
23/12/11
Transaction in Own Shares
29/12/11
Transaction in Own Shares
03/01/12
Total Voting Rights
04/01/12
Transaction in Own Shares
04/01/12
Director/PDMR Shareholding
05/01/12
Transaction in Own Shares
06/01/12
Transaction in Own Shares
09/01/12
Transaction in Own Shares
09/01/12
Reaffirms financial guidance for 2011
10/01/12
Transaction in Own Shares
11/01/12
Transaction in Own Shares
12/01/12
Transaction in Own Shares
13/01/12
Transaction in Own Shares
16/01/12
Transaction in Own Shares
18/01/12
Transaction in Own Shares
19/01/12
FDA complete response letter for Dapagliflozin
19/01/12
Transaction in Own Shares
20/01/12
Transaction in Own Shares
23/01/12
Transaction in Own Shares
24/01/12
Transaction in Own Shares
25/01/12
Transaction in Own Shares
26/01/12
Transaction in Own Shares
27/01/12
Transaction in Own Shares
30/01/12
Transaction in Own Shares
31/01/12
Transaction in Own Shares
01/02/12
Transaction in Own Shares
01/02/12
Notice of Results
01/02/12
Total Voting Rights
02/02/12
Final Results – Part 1 of 3
02/02/12
Final Results – Part 2 of 3
02/02/12
Final Results – Part 3 of 3
02/02/12
Transaction in Own Shares
02/02/12
Share Repurchase Programme
03/02/12
Transaction in Own Shares
03/02/12
Director/PDMR Shareholding
03/02/12
Holding(s) in Company
06/02/12
Transaction in Own Shares
07/02/12
Transaction in Own Shares
08/02/12
Transaction in Own Shares
09/02/12
Transaction in Own Shares
10/02/12
Transaction in Own Shares
13/02/12
Transaction in Own Shares
 
 
 

 
 
14/02/12
Transaction in Own Shares
15/02/12
Transaction in Own Shares
16/02/12
Transaction in Own Shares
16/02/12
Director Declaration
17/02/12
Transaction in Own Shares
20/02/12
Transaction in Own Shares
21/02/12
Transaction in Own Shares
21/02/12
EU approves Caprelsa for thyroid cancer
22/02/12
Transaction in Own Shares
23/02/12
Transaction in Own Shares
24/02/12
Transaction in Own Shares
27/02/12
Transaction in Own Shares
27/02/12
Director/PDMR Shareholding
27/02/12
Director/PDMR Shareholding
27/02/12
Director/PDMR Shareholding
28/02/12
Transaction in Own Shares
28/02/12
Director/PDMR Shareholding
28/02/12
Director/PDMR Shareholding
28/02/12
Director/PDMR Shareholding
29/02/12
Transaction in Own Shares
01/03/12
Announces Non-Executive and Chairman changes
01/03/12
Total Voting Rights
02/03/12
Transaction in Own Shares
02/03/12
Share Repurchase Programme
06/03/12
Transaction in Own Shares
07/03/12
Transaction in Own Shares
08/03/12
Transaction in Own Shares
09/03/12
Transaction in Own Shares
12/03/12
Transaction in Own Shares
13/03/12
Transaction in Own Shares
13/03/12
Files lawsuit against FDA decision on quetiapine
14/03/12
Transaction in Own Shares
15/03/12
Transaction in Own Shares
16/03/12
Transaction in Own Shares
19/03/12
Transaction in Own Shares
20/03/12
Transaction in Own Shares
20/03/12
TC-5214 Phase III studies do not meet endpoint
21/03/12
Transaction in Own Shares
22/03/12
Transaction in Own Shares
22/03/12
UK Court finds Seroquel XR patent invalid
23/03/12
Transaction in Own Shares
26/03/12
US Court dismisses lawsuit against the FDA
26/03/12
Transaction in Own Shares
26/03/12
Annual Financial Report
27/03/12
Transaction in Own Shares
28/03/12
Transaction in Own Shares
28/03/12
Director/PDMR Shareholding
28/03/12
Director/PDMR Shareholding
28/03/12
Director/PDMR Shareholding
29/03/12
Transaction in Own Shares
 
 
 

 
 
29/03/12
Filing of Annual Report on Form 20-F with SEC
29/03/12
Director/PDMR Shareholding
30/03/12
US Court Finds Seroquel XR Patent Valid
30/03/12
Transaction in Own Shares
30/03/12
Director/PDMR Shareholding
02/04/12
Transaction in Own Shares
02/04/12
Total Voting Rights
02/04/12
Director/PDMR Shareholding
02/04/12
Director/PDMR Shareholding
02/04/12
Director/PDMR Shareholding
02/04/12
Director/PDMR Shareholding
03/04/12
Transaction in Own Shares
03/04/12
Partners Amgen to develop inflammation portfolio
04/04/12
Transaction in Own Shares
05/04/12
Transaction in Own Shares
10/04/12
Transaction in Own Shares

All of the above documents are available for download on the Prices and News section of the London Stock Exchange website, www.londonstockexchange.com.

2.
Documents filed at Companies House

The documents listed below were filed with the Registrar of Companies in England and Wales on or around the dates indicated.

Date
Document type
   
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
15/04/11
Form SH03 – Return of Purchase of Own Shares
18/04/11
Form CH01 – Change of Director’s Details
06/05/11
Form TM01 – Resignation of Director
10/05/11
Resolutions of Annual General Meeting
21/06/11
Form AR01 – Annual Return made up to 15/05/11
21/06/11
Group Accounts made up to 31/12/10
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
 
 
 

 
 
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
07/07/11
Form SH03 – Return of Purchase of Own Shares
08/07/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
24/08/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
10/10/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
02/12/11
Form SH03 – Return of Purchase of Own Shares
06/12/11
Form AD02 – Change of SAIL Address
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
10/01/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
 
 
 

 
 
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
20/02/12
Form SH03 – Return of Purchase of Own Shares
16/03/12
Form SH03 – Return of Purchase of Own Shares
16/03/12
Form SH03 – Return of Purchase of Own Shares
16/03/12
Form SH03 – Return of Purchase of Own Shares
16/03/12
Form SH03 – Return of Purchase of Own Shares
20/03/12
Form CH01 – Change of Director’s Details
10/04/12
Form SH03 – Return of Purchase of Own Shares
10/04/12
Form SH03 – Return of Purchase of Own Shares
10/04/12
Form SH03 – Return of Purchase of Own Shares

All of the documents above are available for download from the Companies House website at www.companieshouse.gov.uk, or can be obtained from Companies House, Crown Way, Maindy, Cardiff, CF14 3UZ.

3.
Documents submitted to the FSA

The documents listed below were submitted to The National Storage Mechanism (NSM) on or around the dates indicated.

Date
Document
   
26/03/12
Letter from the Chairman
26/03/12
Notice of AGM 2012 and Shareholder’s Circular
26/03/12
AstraZeneca 2011 In Brief
26/03/12
AstraZeneca Annual Report and Form 20-F Information 2011

All of the above documents are available for download from the NSM website at www.Hemscott.com/nsm.do. The Letter from the Chairman, Notice of AGM 2012, AstraZeneca 2011 In Brief and Annual Report and Form 20-F Information 2011 are also available via the Investors section of our website, www.astrazeneca.com.

4.
Documents lodged with the Securities and Exchange Commission

The documents listed below were filed with the SEC on or around the dates indicated.

Date
Document
   
08/04/11
Form 6-K
28/04/11
Form 20-F
03/05/11
Form F-6EF
 
 
 

 
 
09/05/11
Form 6-K
03/06/11
Form 6-K
07/07/11
Form 6-K
02/08/11
Form 6-K
02/09/11
Form 6-K
07/10/11
Form 6-K
07/11/11
Form 6-K
09/12/11
Form 6-K
04/01/12
Form 6-K
06/02/12
Form 6-K
13/02/12
Form SC 13G/A
05/03/12
Form 6-K
28/03/12
Form 20-F
05/04/12
Form 6-K

All of the documents above are available for viewing on the Investor section of our website, www.astrazeneca.com.

5. 
Further Information

Further information about AstraZeneca PLC can be found at our website, www.astrazeneca.com.

A C N Kemp
Company Secretary
11 April 2012

 
 

 

Item 14

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 305,856 ordinary shares of AstraZeneca PLC at a price of 2782 pence per share on 11 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,272,690,629.


A C N Kemp
Company Secretary
12 April 2012

 
 

 

Item 15

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 304,443 ordinary shares of AstraZeneca PLC at a price of 2795 pence per share on 12 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,272,470,727.


A C N Kemp
Company Secretary
13 April 2012

 
 

 

Item 16

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 305,113 ordinary shares of AstraZeneca PLC at a price of 2789 pence per share on 13 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,272,269,582.


A C N Kemp
Company Secretary
16 April 2012

 
 

 

Item 17

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 304,214 ordinary shares of AstraZeneca PLC at a price of 2797 pence per share on 16 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,988,473.


A C N Kemp
Company Secretary
17 April 2012

 
 

 

Item 18

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 301,651 ordinary shares of AstraZeneca PLC at a price of 2821 pence per share on 17 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,744,799.


A C N Kemp
Company Secretary
18 April 2012

 
 

 

Item 19

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 300,622 ordinary shares of AstraZeneca PLC at a price of 2831 pence per share on 18 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,610,673.


A C N Kemp
Company Secretary
19 April 2012

 
 

 

Item 20

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 301,265 ordinary shares of AstraZeneca PLC at a price of 2825 pence per share on 19 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,368,223.


A C N Kemp
Company Secretary
20 April 2012

 
 

 

Item 21

FORXIGA (DAPAGLIFLOZIN) RECEIVES POSITIVE CHMP OPINION IN THE EUROPEAN
UNION FOR THE TREATMENT OF TYPE 2 DIABETES


AstraZeneca and Bristol-Myers Squibb Company today announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended the approval of FORXIGA (dapagliflozin) tablets for the treatment of type 2 diabetes, as an adjunct to diet and exercise, in combination with other glucose-lowering medicinal products including insulin, and as a monotherapy in metformin intolerant patients.

Dapagliflozin is an investigational selective and reversible inhibitor of sodium-glucose co-transporter 2 (SGLT2), which works independently of insulin. This is the first in the new SGLT2 class to receive a positive CHMP opinion for the treatment of type 2 diabetes, a disease where high unmet medical need exists.
 
The positive opinion was reached after the CHMP reviewed data from a comprehensive clinical development programme that included 11 core Phase III trials assessing the safety and efficacy of dapagliflozin as a once-daily oral therapy. These trials involved 5,693 patients with type 2 diabetes, including 3,939 patients treated with dapagliflozin.

Dapagliflozin 10mg is intended as a once-daily oral dose in adult patients with type 2 diabetes to improve glycaemic control:
 
·  
As a monotherapy, when diet and exercise alone do not provide adequate glycaemic control in patients for whom use of metformin is considered inappropriate due to intolerance;
 
·  
In combination with other glucose-lowering medicinal products including insulin, when these, together with diet and exercise, do not provide adequate glycaemic control.

David Brennan, Chief Executive Officer, AstraZeneca, said: “We are pleased the CHMP has given a positive assessment of the benefit/risk profile of this novel product in a new class for the treatment of type 2 diabetes, an area of high unmet medical need.”

The CHMP's positive opinion on dapagliflozin will now be reviewed by the European Commission, which has the authority to approve medicines for the European Union.

About SGLT2 Inhibition
The kidney plays an important role in glucose balance, normally filtering ~180g of glucose each day, with virtually all glucose being reabsorbed back into circulation. SGLT2 is a major sodium-glucose co-transporter in the kidney and is an insulin-independent pathway for the re-absorption of glucose back into the blood. Selective inhibition of SGLT2 facilitates the excretion of glucose and associated calories in the urine, thereby lowering blood glucose levels.


 
 

 

About Type 2 Diabetes
At the end of 2011, diabetes was estimated to have affected nearly 53 million people aged 20-79 in Europe, and this figure is projected to rise to more than 64 million by 2030. Type 2 diabetes accounts for approximately 85 to 95% of all cases of diagnosed diabetes in adults.  Type 2 diabetes is a chronic disease characterised by insulin resistance and/or dysfunction of beta cells in the pancreas, which decreases insulin sensitivity and secretion, leading to elevated blood glucose levels. Over time, this sustained hyperglycaemia contributes to worsening insulin resistance and further beta cell dysfunction. Significant unmet need exists as many patients remain uncontrolled on their current glucose-lowering regimen.

Bristol-Myers Squibb and AstraZeneca Collaboration
Bristol-Myers Squibb and AstraZeneca entered into a collaboration in January 2007 to enable the companies to research, develop and commercialise select investigational drugs for type 2 diabetes. The Bristol-Myers Squibb/AstraZeneca Diabetes collaboration is dedicated to global patient care, improving patient outcomes and creating a new vision for the treatment of type 2 diabetes.

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines for gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com.

Media Enquiries
Esra Erkal-Paler
+44 20 7604 8030 (24 hours)
Sarah Lindgreen
+44 20 7604 8033 (24 hours)
   
Investor Enquiries UK
James Ward-Lilley
+44 20 7604 8122  mob: +44 7785 432613
Karl Hård
+44 20 7604 8123  mob: +44 7789 654364
Nicklas Westerholm
+44 20 7604 8124  mob: +44 7585 404950
   
Investor Enquiries US
Ed Seage
+1 302 886 4065   mob: +1 302 373 1361
Jorgen Winroth
+1 212 579 0506   mob: +1 917 612 4043


20 April 2012

– ENDS –
 
 

 
 
Item 22

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 298,556 ordinary shares of AstraZeneca PLC at a price of 2850 pence per share on 20 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,150,503.


A C N Kemp
Company Secretary
23 April 2012
 
 
 

 
 
Item 23

 
ASTRAZENECA TO ACQUIRE ARDEA BIOSCIENCES FOR $1 BILLION (NET OF
EXISTING CASH) INCLUDING LEAD PRODUCT LESINURAD IN PHASE III
DEVELOPMENT FOR GOUT
 
AstraZeneca and Ardea Biosciences, Inc. (Ardea) today announced that they have entered into a definitive merger agreement, pursuant to which AstraZeneca will acquire Ardea, a San Diego, California-based biotechnology company focused on the development of small-molecule therapeutics.  Ardea’s clinically most advanced product candidate, lesinurad (formerly known as RDEA594), is currently in Phase III development as a potential treatment for the chronic management of hyperuricaemia in patients with gout.

Under the terms of the agreement, AstraZeneca will acquire Ardea for $32 per share which represents a total cash value of approximately $1.26 billion, including existing cash. This represents a premium on the value of Ardea’s stock of 50% based on the one month volume-weighted average price (VWAP) and 54% based on the closing price on Friday, 20 April 2012.

Lesinurad is a selective inhibitor of URAT1, a transporter in the proximal tubule cells of the kidney that regulates uric acid excretion from the body, which is being developed as an oral, once-daily treatment for the chronic management of hyperuricaemia in patients with gout.  Lesinurad is being studied in an ongoing Phase III clinical development programme as an add-on treatment to allopurinol in patients not reaching target serum uric acid levels on allopurinol alone, as monotherapy for those patients who are intolerant to allopurinol or febuxostat and as an add-on treatment to febuxostat in patients with tophaceous gout.  Filings for a New Drug Application (NDA) in the US and a Marketing Authorisation Application (MAA) in the EU are planned for the first half of 2014.  AstraZeneca also plans to develop and commercialise lesinurad in China and Japan. AstraZeneca will supplement Ardea’s existing capabilities to progress lesinurad Phase III development programme and regulatory submissions. The company will seek to absorb the further development costs of the Ardea compounds in its existing R&D programme.

Through this acquisition, AstraZeneca would also add to its pipeline RDEA3170, a next-generation selective URAT1 inhibitor currently in Phase I development.

“This attractive Phase III programme is an excellent opportunity to leverage AstraZeneca’s global specialty and primary care sales and marketing capabilities,” said David Brennan, Chief Executive Officer of AstraZeneca. “The Ardea team has done a great job developing lesinurad along with a promising next-generation gout programme.  These compounds have real potential to benefit patients.”

“We are delighted to be joining AstraZeneca,” said Barry D. Quart, President and Chief Executive Officer of Ardea. “From our earliest interactions, we were impressed with the quality of AstraZeneca’s people and we are confident their commercial strength and global reach will help realise the full potential of our programmes.  The Ardea team and I are committed to helping complete development and working to secure registration for lesinurad.”
 
 
 

 
 
The Boards of Directors of AstraZeneca and Ardea have unanimously approved the terms of the agreement, and Ardea’s Board has recommended that its shareholders approve the transaction.  Subject to the approval of Ardea’s shareholders as well as other conditions including customary regulatory approvals, the transaction will close in the second or third quarter of 2012. Ardea shareholders representing approximately 30% of the current total shares outstanding have entered into a voting agreement with AstraZeneca to vote in favour of the transaction.

About Gout
Gout is a painful, debilitating and progressive disease caused by abnormally elevated levels of uric acid in the blood stream. This leads to the deposition of painful, needle-like uric acid crystals in and around the connective tissue of the joints and in the kidneys.

It is estimated that there were approximately 14.7 million diagnosed prevalent cases of chronic gout in the major markets in 2009, which is forecast to grow to 16.6 million in 2019.

About Ardea
Ardea is a biotechnology company based in San Diego, California, focused on the development of small-molecule therapeutics for the treatment of serious diseases. Ardea’s most advanced clinical-stage product candidates include lesinurad, formerly known as RDEA594, a selective, oral URAT1 transporter inhibitor for the chronic management of hyperuricaemia in patients with gout and BAY 86-9766, formerly known as RDEA119, a specific inhibitor of mitogen-activated ERK kinase (MEK) for the treatment of cancer which is being developed under a global license agreement with Bayer HealthCare. For more information please visit: www.ardeabio.com.

 
Ardea shareholder information
In connection with the proposed acquisition and required stockholder approval, Ardea will file with the SEC a proxy statement. The proxy statement will be mailed to the stockholders of Ardea. Ardea’s stockholders are urged to read the proxy statement and other relevant materials when they become available because they will contain important information about the acquisition and the company. Investors and security holders may obtain free copies of these documents (when they are available) and other documents filed with the Securities and Exchange Commission at the SEC’s web site at www.sec.gov. In addition, investors and security holders may obtain additional details on the transaction as well as free copies of the documents filed with the SEC by Ardea by going to Ardea’s Investor Relations page on its corporate website as above.

Ardea and its officers and directors may be deemed to be participants in the solicitation of proxies from Ardea’s stockholders with respect to the acquisition. Information about Ardea’s executive officers and directors and their ownership of Ardea stock is set forth in the proxy statement for the Ardea 2012 Annual Meeting of Stockholders, which was filed with the SEC on April 10, 2012. Investors and security holders may obtain more detailed information regarding the direct and indirect interests of the Ardea and its respective executive officers and directors in the acquisition by reading the preliminary and definitive proxy statements regarding the merger, which will be filed with the SEC.

 
 

 

About AstraZeneca
AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialisation of prescription medicines for gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. For more information please visit: www.astrazeneca.com
 
Media Enquiries UK    
Esra Erkal-Paler +44 207 604 8030  
Sarah Lindgreen +44 20 7604 8033  
     
Investor Enquiries UK
   
James Ward-Lilley
Karl Hård
+44 207 604 8122
+44 20 7604 8123
mob: +44 7785 432613
mob: +44 7789 654364
Nicklas Westerholm
 
+44 20 7604 8124
mob: +44 7585 404950
Investor Enquiries US
   
Ed Seage
+1 302 886 4065
mob: +1 302 373 1361
Jorgen Winroth
+1 212 579 0506
mob: +1 917 612 4043


23 April 2012

- ENDS –

 
 

 
 
Item 24

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 301,492 ordinary shares of AstraZeneca PLC at a price of 2823 pence per share on 23 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,271,212,101.


A C N Kemp
Company Secretary
24 April 2012
 
 
 

 
 
Item 25

REPURCHASE OF SHARES IN ASTRAZENECA PLC


Further to the announcement of its irrevocable, non-discretionary share repurchase programme for the period 5 March 2012 to 11 May 2012, AstraZeneca PLC announced that under the terms of that programme it purchased for cancellation 300,636 ordinary shares of AstraZeneca PLC at a price of 2831 pence per share on 24 April 2012. Upon the cancellation of these shares, the number of shares in issue will be 1,270,972,238.


A C N Kemp
Company Secretary
25 April 2012
 
 

 
 
Item 26

ASTRAZENECA FIRST QUARTER RESULTS 2012>

Tomorrow, Thursday, 26 April 2012, AstraZeneca will release first quarter results 2012 at 07:00 BST.

An analysts’ presentation of the first quarter results will take place at 12:00 BST and will be accessible by a choice of two routes:

1)  
Audio webcast (available at http://www.astrazeneca.com/financial-results). You will be able to email questions to the presenters during the Q&A session.

2)  
Teleconference with Q&A.  Dial in numbers:

UK (freephone):
0800 694 2370
International:
+44 (0) 1452 557 749
Sweden (freephone):
0200 883 079
US (freephone):
1 866 977 7645
   
Conference ID:  67777263
 
Printable pdf versions of slides will be available to download on the AstraZeneca Investor Relations website (http://www.astrazeneca.com/financial-results) 15 minutes before the analysts presentation begins.

Details of the teleconference and webcast replay facilities are available on the Investor Relations section of the AstraZeneca website http://www.astrazeneca.com/financial-results and the AstraZeneca Events website: http://info.astrazenecaevents.com.

 
 

 
 
Item 27
 
 
AstraZeneca PLC
FIRST QUARTER RESULTS 2012

 

London, 26 April 2012
 
First quarter results reflect challenging revenue picture.  Pipeline strengthened by Amgen collaboration, the agreement to acquire Ardea Biosciences and positive CHMP opinion for FORXIGATM (dapagliflozin) in Europe.
 
Revenue for the first quarter was $7,349 million, down 11 percent at constant exchange rates (CER).
 
-Loss of exclusivity on several key brands accounted for 8 percentage points of the revenue decline, which included the recognition of a $223 million returns reserve against US trade inventories of Seroquel IR following generic launches at the end of March 2012.
 
-Emerging Markets revenue increased by 1 percent at CER, reflecting the quarterly phasing that the Company anticipated.  Company anticipates a rebound in the remaining three quarters, but achieving double-digit growth for the full year may be a challenge.
 
Core EPS was $1.81 in the first quarter, a 19 percent decline at CER compared with the first quarter last year, which benefited by $0.46 from two one-off gains.  Excluding these gains, Core EPS would have increased by 2 percent compared with last year.
 
-Core gross margin in the first quarter 2011 included a $131 million benefit ($0.07 per share) from settlement of patent disputes with PDL BioPharma, Inc.
 
-Core EPS in the first quarter 2011 benefited by $0.39 as a result of agreements reached between the UK and US governments over certain tax matters.
 
The third phase of the restructuring programme is being implemented with pace, reflected in the $702 million in restructuring costs taken in the first quarter.
 
Reported EPS was down 39 percent at CER to $1.28.
 
-Decline in Reported EPS is significantly larger than the decline in Core EPS, largely the result of restructuring costs that were $0.37 higher than the first quarter 2011.
 
Net cash distributions to shareholders in the first quarter were $3,417 million, through dividend payments of $2,505 million and net share repurchases of $912 million.
 
Core EPS target range for the full year lowered to $5.85 to $6.15.>

Financial Summary

  Group
 
1st Quarter
2012
$m
 
1st Quarter
2011
$m
 
Actual
%
 
CER
%
   
  Revenue
7,349
 
8,292
 
-11
 
-11
   
  Reported
                 
      Operating Profit
2,160
 
3,401
 
-36
 
-37
   
      Profit before Tax
2,053
 
3,288
 
-38
 
-38
   
      Earnings per Share
$1.28
 
$2.08
 
-38
 
-39
   
  Core*
                 
      Operating Profit
2,997
 
3,678
 
-19
 
-18
   
      Profit before Tax
2,890
 
3,565
 
-19
 
-19
   
      Earnings per Share
$1.81
 
$2.23
 
-19
 
-19
   
                   

 
*
Core financial measures are supplemental non-GAAP measures which management believe enhance understanding of the Company’s performance; it is upon these measures that financial guidance for 2012 is based.  See page 2 for a definition of Core financial measures and a reconciliation of Core to Reported financial measures.

 
1

 

David Brennan, Chief Executive Officer, commenting on the results, said>:  “The anticipated impact from the loss of exclusivity on several brands, together with challenging market conditions, has made for a difficult start to the year in revenue terms.  Delivery on our restructuring plans and continued discipline on operating costs, together with the benefits from a lower tax rate, will only partially mitigate the revenue pressures.  As a result we have lowered our Core EPS target for the full year to the range of $5.85 to $6.15.”
 
“The recently announced collaboration with Amgen on a portfolio of five clinical stage projects in the field of inflammation illustrates our willingness to look beyond our laboratories to invest in innovative science wherever it originates.  Our agreement to acquire Ardea Biosciences will add a promising Phase III project for the chronic management of hyperuricaemia in patients with gout. Lastly, we are pleased that the European Union’s CHMP has issued a positive recommendation for regulatory approval for FORXIGA™ (dapagliflozin); together with our partner Bristol-Myers Squibb we look forward to making this new medicine available to patients with diabetes,” Brennan said.
 
 
Operating and Financial Review

 
All narrative in this section refers to growth rates at constant exchange rates (CER) and on a Core basis unless otherwise indicated.  These measures, which are presented in addition to our Reported financial information, are non-GAAP measures which management believe useful to enhance understanding of the Group’s underlying financial performance of our ongoing businesses and the key business drivers thereto.  Core financial measures are adjusted to exclude certain significant items, such as charges and provisions related to our global restructuring programmes, amortisation and impairment of the significant intangibles relating to our acquisition of MedImmune Inc. in 2007 and our current and future exit arrangements with Merck in the US, and other specified items.  More detail on the nature of these measures is given on page 84 of our Annual Report and Form 20-F Information 2011.
 
First Quarter

All financial figures, except earnings per share, are in $ millions.  Weighted average shares in millions.

 
Reported
2012
Restructuring
Merck &
MedImmune
Amortisation
Intangible
Impairments
Legal
Provisions
& Other
Core
2012
Core
2011
Actual
%
CER
%
Revenue
7,349 
-
7,349 
8,292 
(11)
(11)
Cost of Sales
(1,375)
55 
-
(1,320)
(1,327)
   
Gross Profit
5,974 
55 
-
6,029 
6,965 
(13)
(13)
% sales
81.3%
       
82.0%
84.0%
-2.0 
-1.9 
Distribution
(76)
-
(76)
(80)
(5)
(3)
% sales
1.0%
       
1.0%
1.0%
      -
-0.1 
R&D
(1,530)
445 
-
(1,085)
(1,072)
% sales
20.8%
       
14.7%
12.9%
-1.8 
-1.9 
SG&A
(2,461)
202 
117 
-
(2,138)
(2,350)
(9)
(9)
% sales
33.5%
       
29.1%
28.3%
-0.8 
-0.8 
Other Income
253 
14 
-
267 
215 
24 
25 
% sales
3.4%
       
3.6%
2.6%
+1.0 
+1.1 
Operating Profit
2,160 
702 
131*
-
2,997 
3,678 
(19)
(18)
% sales
29.4%
       
40.8%
44.4%
-3.6 
-3.6 
Net Finance Expense
(107)
-
(107)
(113)
   
Profit before Tax
2,053 
702 
131 
-
2,890 
3,565 
(19)
(19)
Taxation
(411)
(141)
(18)*
-
(1)
(571)
(439)
   
Profit after Tax
1,642 
561 
113 
-
2,319 
3,126 
(26)
(26)
Non-controlling Interests
(2)
-
(2)
(8)
   
Net Profit
1,640 
561 
113 
-
2,317 
3,118 
(26)
(26)
Weighted Average Shares
1,281 
1,281 
1,281 
1,281
1,281 
1,281 
1,397 
   
Earnings per Share
1.28 
0.44 
0.09 
-
1.81 
2.23 
(19)
(19)

 
*
Of the $131 million amortisation adjustment, $90 million is related to MedImmune, with a corresponding tax adjustment of $18 million; Merck related amortisation was $41 million, which carries no tax adjustment.

Revenue in the first quarter was down 11 percent at CER and on an actual basis as exchange rate movements were neutral to reported revenue.  The disposal of Astra Tech last year accounted for 1.7 percent of the revenue decline.  Loss of exclusivity for several products, chiefly Seroquel IR, Nexium and Arimidex, accounted for 8 percent of the decline in revenue. Shortfalls in the supply of some products caused by the implementation of a new enterprise resource planning IT system at the Company’s manufacturing plant in Sweden reduced revenues by just under 1 percent in the first quarter.  Though the underlying problems have now been largely resolved, we anticipate further limitation in the supply chain in some markets during the second quarter as production responds to ongoing demand, fulfilling back orders and restoring normal inventory levels.
 
 
2

 
 
US revenues were down 12 percent.  Generic competition for Seroquel IR commenced at the end of March.  In line with the Company’s established practice, a returns reserve was taken against the estimated trade inventories of Seroquel IR; this amounted to $223 million, or around 7 percentage points of the decline in US revenues for the quarter. The negative impact of US healthcare reform on first quarter revenue was $205 million, including a $38 million adjustment in the Medicare coverage gap discounts related to 2011 utilisation.

Revenue in the Rest of World (ROW) was down 11 percent.  Revenue in Western Europe was down 19 percent, chiefly on generic competition and lower realised prices.  Revenue in Established ROW was down 9 percent.  Revenue in Emerging Markets was up 1 percent, in line with expectations for a quarterly phasing of revenue that would be biased towards the remaining three quarters of the year.  Revenue declines in just three markets (Brazil, Turkey and Mexico) accounted for more than 40 percent of the shortfall from recent double-digit growth rates for Emerging Markets. We expect a rebound in the remaining three quarters of the year, but achieving double-digit growth for the full year may be a challenge.

Compared with the 11 percent decline in revenue, Core gross margin declined by 13 percent.  Core gross margin in the first quarter of 2011 included a $131 million benefit from the settlement of patent disputes between MedImmune and PDL BioPharma, Inc.  This accounted for 1.6 percentage points of the 1.9 percentage point decline in gross margin in the first quarter 2012 compared to the first quarter last year.

Expenditures in Core SG&A were down 9 percent, as benefits from restructuring and overall lower sales and marketing expenses in developed markets more than offset selective investments in Emerging Markets.  The excise fee imposed by the enactment of US healthcare reform measures amounted to 2.8 percent of SG&A expense in the quarter.

Core other income of $267 million was up 25 percent.  The first quarter 2012 includes the impact from the licensing of US commercial rights for Zomig to Impax Laboratories; AstraZeneca now recognises the commercial contribution from Zomig in other income, rather than in revenue.

Core Pre-R&D operating profit was down 14 percent to $4,082 million.  Core Pre-R&D operating margin was 55.5 percent of revenue, above the top of our 48 to 54 percent planning range, but down 1.7 percentage points compared with last year.  Lower revenue and gross margin was only partially offset by lower SG&A expenses and higher other income.

Core R&D expense increased by 2 percent in the first quarter, with the increase largely attributable to a net increase in intangible asset impairments compared with last year ($50 million related to TC-5214 in the first quarter 2012). For the full year, Core R&D expense is expected to be lower than last year on a constant currency basis.

Core operating profit was down 18 percent to $2,997 million, on the declines in revenue and Core Pre-R&D operating margin combined with the slightly higher Core R&D expense.

Core earnings per share were down 19 percent to $1.81, with the negative impact from a higher tax rate compared with the first quarter 2011 (which benefited from tax settlements) broadly offset by the benefit from the lower number of shares outstanding as a result of net share repurchases.

Reported operating profit was down 37 percent to $2,160 million.  Reported EPS was down 39 percent to $1.28.  The larger declines compared to the declines for Core profit measures are largely the result of higher restructuring costs in the first quarter of 2012 ($702 million) compared with the first quarter last year ($143 million).

Enhancing Productivity

The Company is making good progress in implementing the third phase of restructuring announced in February 2012, as evidenced by the $702 million in restructuring charges taken in the first quarter (of which $445 million was in R&D). This first quarter charge is one third of the estimated total programme cost of $2.1 billion.  It is anticipated that most of the total restructuring costs will be taken in 2012.

The programme is on track to deliver the $1.6 billion in annual benefits by the end of 2014.

Finance Income and Expense

Net finance expense was $107 million for the quarter, versus $113 million in 2011.  There was a $6 million reduction in interest payable on defined benefit pension scheme liabilities compared to the first quarter 2011.  Interest payable on debt balances and fair value losses recorded on long-term bonds were broadly unchanged versus the first quarter 2011.
 
 
3

 
 
Taxation

The effective tax rate for the first quarter was 20.0 percent compared with 11.3 percent for the same period last year. The full year reported tax rate is now anticipated to be around 22 percent (reduced from 24 percent) as a result of a UK tax rate reduction, resolution of tax audit issues in the first quarter and variations in the levels and mix of profitability in different jurisdictions.

The effective tax rate for the first quarter of last year benefited from a favourable adjustment to tax provisions of $540 million following the announcement in March 2011 that HM Revenue & Customs in the UK and the US Internal Revenue Service agreed the terms of an Advance Pricing Agreement regarding transfer pricing arrangements for AstraZeneca’s US business for the period from 2002 to the end of 2014 and a related valuation matter. Excluding this benefit, the effective tax rate for the quarter ending 31 March 2011 was 27.8 percent on a reported basis.

Cash Flow

Cash generated from operating activities was $1,540 million in the quarter to 31 March 2012, compared with $1,890 million in the same period of 2011. Improvements in working capital offset the lower operating profit, while increased pension fund contributions drove higher outflows in non-cash and other movements.

Net cash inflows from investing activities were $593 million in the quarter compared with $100 million in the first quarter of 2011. The difference of $493 million is due primarily to the net movement between cash and short-term investments and fixed deposits, and an increase in cash received on the disposal of property, plant and equipment.

Cash distributions to shareholders were $3,417 million through net share repurchases of $912 million and $2,505 million from the payment of the second interim dividend from 2011.

Debt and Capital Structure

At 31 March 2012, outstanding gross debt (interest-bearing loans and borrowings) was $9,383 million (31 December 2011: $9,328 million). Of the gross debt outstanding at 31 March 2012, $2,006 million is due within one year (31 December 2011: $1,990 million).

Net funds of $943 million have decreased by $1,906 million during the quarter as a result of the net cash outflow as described in the cash flow section above.

Share Repurchases

In the first quarter of 2012 the Group repurchased 22.6 million shares for a total of $1,055 million.  In the quarter, 4.2 million shares were issued in consideration of share option exercises for a total of $143 million.

The total number of shares in issue at 31 March 2012 was 1,274 million.

Future Prospects

The revenue profile for 2012 will be largely defined by the impact of the loss of exclusivity on several products, particularly Seroquel IR.  The disposal of Astra Tech and the ongoing disposal of the Aptium business will also contribute to the decline in revenue.  In addition, the headwinds from government interventions on price are looking to be at the upper end of our planning assumptions for the year.  On balance, we now expect the decline in revenue for the full year will be in the range of the low to mid-teens in constant currency terms.

Against the backdrop of this challenging revenue picture, we are proceeding apace with the third phase of restructuring.  Continued realisation of restructuring benefits, ongoing discipline in operating expenses and a lower projected tax rate for the year will only partially mitigate the downward pressure on revenue.  As a result, we have lowered our Core EPS target for the full year to the range of $5.85 to $6.15.

This Core EPS guidance has been based on January 2012 average exchange rates for our principal currencies, and actual first quarter results were broadly in line with this currency assumption.  The target takes no account of the likelihood that average exchange rates for the remainder of 2012 may differ materially from the rates upon which our earnings guidance is based.  An estimate of the sales and earnings sensitivity to movements of our major currencies versus the US dollar was provided in conjunction with the Full Year 2011 results announcement, and can be found on the AstraZeneca website, www.astrazeneca.com/investors.

 
4

 
 
Research and Development Update

 

A comprehensive update of the AstraZeneca R&D pipeline was presented in conjunction with the Full Year 2011 results and the pipeline table remains available on the Company’s website, www.astrazeneca.com, under information for investors.

Developments since the last update include:

AstraZeneca collaboration with Amgen

On 2 April 2012, AstraZeneca and Amgen announced an agreement to jointly develop and commercialise five monoclonal antibodies from Amgen’s clinical inflammation portfolio: AMG 139, AMG 157, AMG 181, AMG 557 and brodalumab (AMG 827).

The companies believe all the molecules have novel properties and offer the potential to deliver important treatments across multiple indications in inflammatory diseases.

Under the terms of the agreement, AstraZeneca will make a one-time $50 million upfront payment and the companies will share both costs and profits.  Based on current plans, approximately 65 percent of costs for the 2012-14 period will be funded by AstraZeneca.  Thereafter, the companies will split costs equally.  Amgen will book sales globally and retain a low single-digit royalty for brodalumab and a mid single-digit royalty for the rest of the portfolio, after which the companies will share profits equally.

FORXIGATM (dapagliflozin)

On 20 April 2012, AstraZeneca and Bristol-Myers Squibb Company announced that the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) has recommended the approval of FORXIGA™ (dapagliflozin) tablets for the treatment of type 2 diabetes, as an adjunct to diet and exercise, in combination with other glucose-lowering medicinal products including insulin, and as a monotherapy in metformin intolerant patients.

Dapagliflozin is an investigational selective and reversible inhibitor of sodium-glucose co-transporter 2 (SGLT2), which works independently of insulin. This is the first in the new SGLT2 class to receive a positive CHMP opinion for the treatment of type 2 diabetes, a disease where high unmet medical need exists.

Dapagliflozin 10mg is intended as a once-daily oral dose in adult patients with type 2 diabetes to improve glycaemic control:

 
·
As a monotherapy, when diet and exercise alone do not provide adequate glycaemic control in patients for whom use of metformin is considered inappropriate due to intolerance;
 
·
In combination with other glucose-lowering medicinal products including insulin, when these, together with diet and exercise, do not provide adequate glycaemic control.

The CHMP's positive opinion on dapagliflozin will now be reviewed by the European Commission, which has the authority to approve medicines for the European Union.

TC-5214

On 20 March 2012, AstraZeneca and Targacept announced top-line results from the remaining Phase III studies investigating efficacy, tolerability and safety of TC-5214 as an adjunct therapy to an antidepressant in patients with major depressive disorder (MDD) who did not respond adequately to initial antidepressant treatment.  RENAISSANCE 4 and RENAISSANCE 5, both efficacy and tolerability studies, did not meet the primary endpoint of change on the Montgomery-Asberg Depression Rating Scale total score after eight weeks of treatment with TC-5214 as compared with placebo.

Based on the results of these trials, and the totality of the results for all studies in the RENAISSANCE programme, AstraZeneca and Targacept will not pursue a regulatory filing for TC-5214 as an adjunct treatment for patients with MDD.

AstraZeneca took an intangible asset impairment charge of $50 million, the remaining value in relation to TC-5214, in the first quarter 2012.

 
5

 
 
FluMist Quadrivalent

On 1 March 2012, AstraZeneca announced that MedImmune, its biologics arm, received approval from the US FDA for FluMist Quadrivalent (Influenza Vaccine Live, Intranasal) in the prevention of influenza.  This marks the first four-strain influenza vaccine approved by the FDA.

All other licensed seasonal influenza vaccines currently available in the US are trivalent, containing three strains (two strains of type A influenza (A/H1N1 and A/H3N2) and one B lineage strain).  FluMist Quadrivalent contains four strains (two type A strains and two type B strains) to help provide broad protection against circulating influenza A and B.

Caprelsa (vandetanib)

On 21 February 2012, the Company announced that the European Commission granted marketing authorisation for Caprelsa (vandetanib) for the treatment of aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease.  Caprelsa is the first approved treatment for advanced MTC in Europe.

Advanced MTC is a rare disease with a poor prognosis.  Caprelsa was granted orphan drug status and approved by the US FDA in April 2011.  Caprelsa is also approved in Canada and is under review in Russia, Switzerland, Brazil, Mexico, Argentina and Australia.
 
 
6

 
 
Revenue

 

All narrative in this section refers to growth rates at constant exchange rates (CER) unless otherwise indicated.
 
A full analysis of the Group’s revenue by product and geographic area is shown on page 19.

 
First Quarter
         
 
2012
 
2011
 
CER
       
 
$m
 
$m
 
%
       
Gastrointestinal
                 
   Nexium
953
 
1,161
 
-18
       
   Losec/Prilosec
170
 
235
 
-29
       
                   
Cardiovascular
                 
   Crestor
1,500
 
1,478
 
+2
       
   Atacand
317
 
355
 
-9
       
   Seloken /Toprol-XL
224
 
245
 
-8
       
   ONGLYZATM
72
 
35
 
+106
       
   Brilinta/Brilique
9
 
1
 
n/m
       
                   
Respiratory & Inflammation
                 
   Symbicort
723
 
752
 
-3
       
   Pulmicort
227
 
248
 
-8
       
                   
Oncology
                 
   Zoladex
273
 
275
 
-1
       
   Arimidex
144
 
233
 
-39
       
   Casodex
113
 
133
 
-17
       
   Iressa
143
 
121
 
+17
       
   Faslodex
151
 
123
 
+24
       
   Caprelsa
5
 
-
 
n/m
       
                   
Neuroscience
                 
   Seroquel
1,138
 
1,345
 
-15
       
     Seroquel IR
754
 
1,006
 
-25
       
     Seroquel XR
384
 
339
 
+14
       
   Zomig
54
 
101
 
-47
       
   Vimovo
16
 
4
 
+300
       
                   
Infection and other
                 
   Synagis
384
 
408
 
-6
       
   Merrem
100
 
172
 
-40
       
   FluMist
2
 
3
 
-33
       
 
Gastrointestinal
 
· 
In the US, Nexium sales in the first quarter were $535 million, down 11 percent compared with the first quarter last year.  Dispensed retail tablet volume declined by 11 percent.  Nearly 40 percent of the volume decline was related to a 57 percent decline in low margin Medicaid prescriptions; this change in mix resulted in a slight increase in average realised selling prices in the quarter.
 
· 
Nexium sales in other markets were down 25 percent to $418 million.  Sales in Western Europe were down 53 percent, largely the result of generic competition.  Sales in Established Rest of World were down 2 percent, as growth in Japan was more than offset by the impact of generic competition in Canada.  Sales in Emerging Markets increased by 2 percent.
 
· 
Losec sales in markets outside the US were down 28 percent to $162 million.
 
 
7

 
 
Cardiovascular
 
· 
In the US, Crestor sales in the first quarter were $682 million, unchanged from last year.  Total prescriptions for statin products in the US increased by 1.8 percent in the first quarter.   Crestor total prescriptions increased by 2.1 percent, largely unaffected by the launch of generic atorvastatin in November of last year.  The small decline in average realised selling prices is due to the adjustment in the Medicare coverage gap discounts related to 2011 utilisation.
 
· 
Crestor sales in the Rest of World were up 3 percent to $818 million.  Sales in Western Europe were up 5 percent on volume growth partially offset by slightly lower prices.  Sales in Established ROW were up 3 percent, as sales in Japan were unchanged.  Crestor is now the leading statin by volume share in Japan, but continued strong underlying demand was offset by the quarterly phasing of shipments to our marketing partner.  Sales in Emerging Markets were up 1 percent, as growth in China and Emerging Europe was offset by generic erosion in Brazil.
 
· 
US sales of the Toprol-XL product range, which includes sales of the authorised generic, declined by 28 percent to $73 million, largely the result of lower selling prices following the launch of a third generic product late last year.  
 
· 
Sales of Seloken in other markets were up 6 percent to $151 million on 12 percent growth in Emerging Markets.
 
· 
US sales of Atacand were down 13 percent in the quarter, to $40 million.  Sales in other markets were down 9 percent to $277 million, largely due to the 57 percent decline in Canada from generic competition.
 
· 
Alliance revenue from the ONGLYZATM collaboration with Bristol-Myers Squibb totalled $72 million in the first quarter, of which $54 million was in the US and $18 million in other markets.  ONGLYZATM share of total prescriptions for DPP4 products in the US was 11.4 percent in March 2012.  KOMBIGLYZE XRTM added a further 5.1 percent total prescription share to the franchise in the US in March.  Marketing authorisation for KOMBOGLYZETM, the twice daily combination of saxagliptin and immediate-release metformin, was granted by the European Commission in November 2011.  However, due to a technical manufacturing issue launch is not expected until 2013.
 
· 
Sales of Brilinta/Brilique were $9 million in the quarter, chiefly on sales in Germany and some Emerging Markets.  In Germany, in the 79 percent of target hospitals where Brilique is on protocol, Brilique has now overtaken clopidogrel to become the leading product for initial therapy for new ACS patients, with a market share of 37 percent.  There were no reported sales in the US, as initial launch stocks in trade channels are still being worked down; we continue to make steady progress in terms of formulary access, protocol adoption and product trial rates by interventional cardiologists.

 
Respiratory and Inflammation
 
· 
Symbicort sales in the US were $217 million, a 10 percent increase over the first quarter last year.  Total prescriptions for Symbicort were up 11 percent compared to a 1 percent decline in the market for fixed combination products.  Symbicort share of new prescriptions for fixed combination products reached 20.8 percent in March 2012, up 0.5 percentage points since December 2011.  Market share of patients newly starting combination therapy is 25.8 percent.
 
· 
Symbicort sales in other markets in the first quarter were $506 million, down 7 percent.  More than 60 percent of the revenue decline is due to a decrease in Japan (down 59 percent) as a result of destocking by our marketing partner; underlying demand growth remains well above the combination product market growth in Japan.  Sales in Western Europe were down 4 percent.  Sales in Emerging Markets were down 1 percent.
 
· 
US sales of Pulmicort were down 28 percent in the first quarter to $56 million.  Sales in the Rest of World were up 1 percent, driven by a 49 percent increase in China, which more than offset declines in Western and Emerging Europe.
 

 
8

 
 
Oncology
 
· 
Arimidex sales in the US were $7 million in the first quarter.  Arimidex sales in the Rest of World were down 36 percent to $137 million.   Sales in Western Europe were down 64 percent to $37 million, reflecting the loss of exclusivity from February 2011.  Sales in Japan were 8 percent below last year. Sales in Emerging Markets were down 14 percent.
 
· 
Sales for Casodex in the first quarter were down 17 percent to $113 million, all outside of the US.  More than 60 percent of revenue is in Japan, where sales were down 13 percent in the quarter.  Sales were down 39 percent in Western Europe.  Sales in Emerging Markets were down 4 percent.
 
· 
Iressa sales in the first quarter were up 17 percent to $143 million, with a 42 percent increase in Western Europe accounting for more than half of the growth in the quarter.  Sales in Japan were down 2 percent.  Sales in Emerging Markets were up 18 percent.
 
· 
Faslodex sales in the US were up 16 percent, reaching $72 million.  Sales in the Rest of World were up 33 percent to $79 million. The new 500mg dosage regimen has now been widely adopted in many markets, so future growth will increasingly be driven by stronger patient demand rather than dosage upgrade.
 
 
Neuroscience
 
· 
In the US, Seroquel franchise sales were down 20 percent to $741 million.  In line with the Company’s established practice when generic competitors are launched, a returns reserve of $223 million was taken against the estimated trade inventories for Seroquel IR following the launch of generic quetiapine IR at the end of March.  Were it not for this reserve, Seroquel franchise sales would have increased by 4 percent.  Sales of Seroquel XR in the US were up 13 percent to $199 million.  Total prescriptions for Seroquel XR were up 3 percent, which compares favourably to the 1 percent decline for the US atypical antipsychotic market.
 
· 
Seroquel franchise sales in the Rest of World were down 3 percent to $397 million in the quarter. Sales of Seroquel IR were down 16 percent to $212 million.  Seroquel XR sales were up 16 percent to $185 million.  Sales of Seroquel XR were up 15 percent in Western Europe, including a contribution from the launch in France.  Seroquel XR sales were up 15 percent in Established ROW and were up 18 percent in Emerging Markets.
 
· 
Zomig sales in the US were down 87 percent to $5 million, a result of the licensing of US commercial rights for Zomig to Impax Laboratories.  Commercial contribution from Zomig in the US is now realised in other income, rather than in revenue.  Sales in the Rest of World were down 21 percent to $49 million in the quarter.
 
· 
The US accounted for $9 million of the total $16 million sales for Vimovo in the first quarter. ROW sales were $7 million.
 
 
Infection and Other
 
· 
Sales of Synagis in the US were up 3 percent to $302 million. Synagis revenue for the 2011/12 RSV season is slightly down compared with the prior period season; a later RSV season start due to seasonal virology patterns has shifted some volume from the fourth quarter 2011 into the first quarter 2012.  Outside the US, Synagis sales were down 27 percent to $82 million, reflecting the quarterly phasing of shipments to Abbot, our international distributor.
 
· 
Sales of Merrem were down 40 percent to $100 million as a result of generic competition in many markets.

 
 
9

 
 
Regional Revenue
 
 
First Quarter
         
 
2012
 
2011
 
% Change
     
 
$m
 
$m
 
Actual
 
CER
     
US
2,920
 
3,304
 
-12
 
-12
     
Western Europe1
1,775
 
2,235
 
-21
 
-19
     
Established ROW2
1,238
 
1,321
 
-6
 
-9
     
Canada
377
 
417
 
-10
 
-8
     
Japan
598
 
631
 
-5
 
-10
     
Other Established ROW
263
 
273
 
-4
 
-8
     
Emerging ROW3
1,416
 
1,432
 
-1
 
+1
     
Emerging Europe
294
 
320
 
-8
 
-2
     
China
380
 
322
 
+18
 
+13
     
Emerging Asia Pacific
233
 
242
 
-4
 
-2
     
Other Emerging ROW
509
 
548
 
-7
 
-3
     
                     
Total
7,349
 
8,292
 
-11
 
-11
     
                     
1Western Europe comprises France, Germany, Italy, Sweden, Spain, UK and others.
2Established ROW comprises Canada, Japan, Australia and New Zealand.
3Emerging ROW comprises Brazil, China, India, Mexico, Russia, Turkey and all other ROW countries

· 
In the US, revenue was down 12 percent, with the inventory reserve for Seroquel IR accounting for $223 million of the $384 million decline in revenue.  The pricing impact of US healthcare reform measures amounted to $205 million in the quarter.  There was good growth for ONGLYZATM, Seroquel XR and Symbicort, but this was more than offset by a decline for Nexium, generic erosion on Toprol-XL, Arimidex and Merrem, the movement of Zomig revenue to other income, the disposal of Astra Tech and the ongoing disposal of the Aptium business.
 
· 
Revenue in Western Europe was down 19 percent, with generic competition for Nexium, Arimidex and Merrem accounting for nearly 60 percent of the revenue decline.  Sales growth was achieved for Seroquel XR, Crestor, Iressa and ONGLYZATM.
 
· 
Revenue in Established ROW was down 9 percent.  Revenue in Japan was down 10 percent, reflecting destocking ahead of the biennial price reductions and the quarterly phasing of shipments of Crestor and Symbicort to marketing partners.  Revenue in Canada was down 8 percent, chiefly due to generic competition for Nexium and Atacand.
 
· 
Revenue in Emerging Markets was up 1 percent, driven by the 13 percent increase in China.  The weak first quarter revenue performance was expected, with difficult year on year comparisons for Brazil, Turkey and Mexico.  There has been generic competition for Crestor and Seroquel IR in Brazil.  Government interventions in price have affected revenue in Turkey.  Performance in Mexico reflects challenging market conditions.  The Company anticipates revenue in Emerging Markets to rebound in the remaining quarters, but achieving double-digit growth for the full year may be a challenge.
 
 
10

 
 
Condensed Consolidated Statement of Comprehensive Income
 
For the quarter ended 31 March
 
2012 
$m 
 
2011 
$m 
Revenue
 
7,349 
 
8,292 
Cost of sales
 
(1,375)
 
(1,339)
Gross profit
 
5,974 
 
6,953 
Distribution costs
 
(76)
 
(80)
Research and development
 
(1,530)
 
(1,162)
Selling, general and administrative costs
 
(2,461)
 
(2,508)
Other operating income and expense
 
253 
 
198 
Operating profit
 
2,160 
 
3,401 
Finance income
 
132 
 
137 
Finance expense
 
(239)
 
(250)
Profit before tax
 
2,053 
 
3,288 
Taxation
 
(411)
 
(373)
Profit for the period
 
1,642 
 
2,915 
Other comprehensive income:
       
Foreign exchange arising on consolidation
 
121 
 
208 
Foreign exchange differences on borrowings forming net investment hedges
 
(50)
 
(92)
Net available for sale gains taken to equity
 
18 
 
11 
Actuarial gain/(loss) for the period
 
74 
 
(18)
Income tax relating to components of other comprehensive income
 
(46)
 
27 
Other comprehensive income for the period, net of tax
 
117 
 
136 
Total comprehensive income for the period
 
1,759 
 
3,051 
         
Profit attributable to:
       
Owners of the parent
 
1,640 
 
2,907 
Non-controlling interests
 
 
   
1,642 
 
2,915 
         
Total comprehensive income attributable to:
       
Owners of the parent
 
1,767 
 
3,045 
Non-controlling interests
 
(8)
 
   
1,759 
 
3,051 
         
Basic earnings per $0.25 Ordinary Share
 
$1.28 
 
$2.08 
Diluted earnings per $0.25 Ordinary Share
 
$1.28 
 
$2.07 
Weighted average number of Ordinary Shares in issue (millions)
 
1,281 
 
1,397 
Diluted weighted average number of Ordinary Shares in issue (millions)
 
1,285 
 
1,404 
 
 
11

 
 
Condensed Consolidated Statement of Financial Position
   
At 31 Mar 2012
$m
 
At 31 Dec 2011
$m
 
At 31 Mar 2011
$m
ASSETS
Non-current assets
           
Property, plant and equipment
 
6,335 
 
6,425 
 
7,062 
Goodwill
 
9,871 
 
9,862 
 
9,890 
Intangible assets
 
11,027 
 
10,980 
 
12,232 
Derivative financial instruments
 
326 
 
342 
 
292 
Other investments
 
204 
 
201 
 
212 
Deferred tax assets
 
1,440 
 
1,514 
 
1,379 
   
29,203 
 
29,324 
 
31,067 
Current assets
           
Inventories
 
2,040 
 
1,852 
 
1,897 
Trade and other receivables
 
8,511 
 
8,754 
 
8,493 
Other investments
 
3,637 
 
4,248 
 
1,199 
Derivative financial instruments
 
31 
 
25 
 
Income tax receivable
 
1,009 
 
1,056 
 
2,289 
Cash and cash equivalents
 
6,332 
 
7,571 
 
9,582 
   
21,560 
 
23,506 
 
23,467 
Total assets
 
50,763 
 
52,830 
 
54,534 
LIABILITIES
Current liabilities
           
Interest-bearing loans and borrowings
 
(2,006)
 
(1,990)
 
(435)
Trade and other payables
 
(8,945)
 
(8,975)
 
(8,672)
Derivative financial instruments
 
 
(9)
 
Provisions
 
(1,683)
 
(1,388)
 
(1,151)
Income tax payable
 
(3,166)
 
(3,390)
 
(5,758)
   
(15,800)
 
(15,752)
 
(16,016)
Non-current liabilities
           
Interest-bearing loans and borrowings
 
(7,377)
 
(7,338)
 
(9,159)
Deferred tax liabilities
 
(2,671)
 
(2,735)
 
(3,168)
Retirement benefit obligations
 
(2,191)
 
(2,674)
 
(2,573)
Provisions
 
(496)
 
(474)
 
(699)
Other payables
 
(507)
 
(385)
 
(372)
   
(13,242)
 
(13,606)
 
(15,971)
Total liabilities
 
(29,042)
 
(29,358)
 
(31,987)
Net assets
 
21,721 
 
23,472 
 
22,547 
EQUITY
           
Capital and reserves attributable to equity holders of the Company
           
Share capital
 
318 
 
323 
 
346 
Share premium account
 
3,220 
 
3,078 
 
2,761 
Other reserves
 
1,952 
 
1,951 
 
1,910 
Retained earnings
 
16,026 
 
17,894 
 
17,332 
   
21,516 
 
23,246 
 
22,349 
Non-controlling interests
 
205 
 
226 
 
198 
Total equity
 
21,721 
 
23,472 
 
22,547 
 
 
12

 
 
Condensed Consolidated Statement of Cash Flows
For the quarter ended 31 March
 
2012 
$m 
 
2011 
$m 
Cash flows from operating activities
       
Profit before taxation
 
2,053 
 
3,288 
Finance income and expense
 
107 
 
113 
Depreciation, amortisation and impairment
 
499 
 
526 
Decrease/(increase) in working capital and short-term provisions
 
364 
 
(864)
Non-cash and other movements
 
(484)
 
(130)
Cash generated from operations
 
2,539 
 
2,933 
Interest paid
 
(248)
 
(241)
Tax paid
 
(751)
 
(802)
Net cash inflow from operating activities
 
1,540 
 
1,890 
Cash flows from investing activities
       
Movement in short-term investments and fixed deposits
 
651 
 
317 
Purchase of property, plant and equipment
 
(122)
 
(161)
Disposal of property, plant and equipment
 
125 
 
24 
Purchase of intangible assets
 
(80)
 
(110)
Purchase of non-current asset investments
 
(2)
 
(1)
Interest received
 
41 
 
46 
Payments made by subsidiaries to non-controlling interests
 
(20)
 
(15)
Net cash inflow from investing activities
 
593 
 
100 
Net cash inflow before financing activities
 
2,133 
 
1,990 
Cash flows from financing activities
       
Proceeds from issue of share capital
 
143 
 
90 
Repurchase of shares for cancellation
 
(1,055)
 
(1,301)
Dividends paid
 
(2,505)
 
(2,646)
Hedge contracts relating to dividend payments
 
13 
 
41 
Movement in short-term borrowings
 
(34)
 
Net cash outflow from financing activities
 
(3,438)
 
(3,807)
Net decrease in cash and cash equivalents in the period
 
(1,305)
 
(1,817)
Cash and cash equivalents at the beginning of the period
 
7,434 
 
10,981 
Exchange rate effects
 
14 
 
30 
Cash and cash equivalents at the end of the period
 
6,143 
 
9,194 
Cash and cash equivalents consists of:
       
Cash and cash equivalents
 
6,332 
 
9,582 
Overdrafts
 
(189)
 
(388)
   
6,143 
 
9,194 
 
 
13

 
 
Condensed Consolidated Statement of Changes in Equity

   
Share
capital
$m
 
Share
premium
account
$m
 
Other*
reserves
$m
 
Retained
earnings
$m
 
Total
$m
 
Non-
controlling
interests
$m
 
Total
equity
$m
At 1 January 2011
 
352 
 
2,672
 
1,917 
 
18,272 
 
23,213 
 
197 
 
23,410 
Profit for the period
 
 
-
 
 
2,907 
 
2,907