BioSphere Medical (BSMD)

Deadline for Submission of Stockholder Proposals for the 2008 Annual Meeting

In order to be included in the proxy material for the 2008 annual meeting of stockholders, stockholders’ proposed resolutions must be received by us at the address set forth above no later than December 11, 2007.

If a stockholder wishes to present a proposal before the 2008 annual meeting of stockholders, but does not wish to have the proposal considered for inclusion on the proxy statement and proxy card, the stockholder must give written notice to us at the address set forth above. The required notice must be given by February 28, 2008. If a stockholder fails to provide timely notice of a proposal to be presented at the 2008 annual meeting of stockholders, the proxies designated by our board of directors will have discretionary authority to vote on that proposal.

The board of directors encourages stockholders to attend the annual meeting. Whether or not you plan to attend, you are urged to complete, date, sign and return the enclosed proxy in the accompanying envelope. A prompt response will greatly facilitate arrangements for the annual meeting and your cooperation will be appreciated. Stockholders who attend the annual meeting may vote their stock personally even though they have sent in their proxies.

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