QUOTE AND NEWS
SeekingAlpha  Aug 13  Comment 
ByAlexander Maxwell: Dendreon Corporation (NASDAQ:DNDN) shareholders got a piece of bad news a few days ago, when the company announced that it was looking at ways to pay off its debt that could include measures that would leave shareholders with...
StreetInsider.com  Aug 12  Comment 
Fortegra Financial Corporation (NYSE: FRF) 40.3% HIGHER; Tiptree Financial and Fortegra Financial jointly announce the signing of a merger agreement pursuant to which Tiptree will acquire Fortegra in an all cash transaction valued at approximately...
The Market Financial  Aug 12  Comment 
Dendreon Corporation (NASDAQ:DNDN) is down 36% to $1.35 after the company said it may have to wipe out shareholder equity in the company to pay off debt. This sounds like a catastrophe but let's explore the nuances to better understand what is...
SeekingAlpha  Aug 12  Comment 
BySharon di Stefano: Tumor cells, tending to persist after treatment, lead to remission and have been a bane to cancer researchers and doctors for decades. Only recently, immuno-oncology, labeled "I-O" first by Bristol-Myers Squibb Co. (NYSE:BMY),...
Motley Fool  Aug 12  Comment 
Dendreon's 10-Q is causing investors some serious heartburn.
Benzinga  Aug 12  Comment 
Dendreon (NASDAQ: DNDN) shares declined 32.55% to $1.43. Dendreon warned investors of a "significant risk" that it will be unable to repay or refinance $620 million in notes due in January 2016. magicJack VocalTec (NASDAQ: CALL) dropped 14.18%...
SeekingAlpha  Aug 12  Comment 
By Bill Maurer: I've spent a lot of time detailing the short thesis for biotech name Dendreon (NASDAQ:DNDN). Shares of the company have continued to plunge, and closed at just $2.12 yesterday. With the company in a period of executive transition,...
Benzinga  Aug 12  Comment 
Dendreon (NASDAQ: DNDN) warned investors of a "significant risk" that it will be unable to repay or refinance $620 million in notes due in January 2016. "We are considering alternatives that could result in leaving our current stockholders...
StreetInsider.com  Aug 12  Comment 
Visit StreetInsider.com at http://www.streetinsider.com/Corporate+News/Dendreon+Corp+%28DNDN%29+Declines+After+Filing+10-Q/9743266.html for the full story.




 
TOP CONTRIBUTORS

Dendreon Corporation (NYSE:DNDN) is a biotechnology company with a focus on developing drugs for cancer. Its most advanced product is Provenge (Sipuleucel-T), approved by the FDA in 2010, is a therapeutic vaccine developed for the treatment of prostate cancer. Successful late-stage clinical trials yielded very positive results that could turn Provenge into a blockbuster therapy. Dendreon is beginning to market Provenge in the U.S. on its own.

Dendreon's success over the next few years will depend both on its ability to expand capacity to keep up with demand for the drug as well as overall success of Provenge in the advanced prostate cancer market.

Business Growth

FY 2010 (ended December 31, 2010

  • Net revenue surpassed $1 million for the first time at $48 million.[1]
  • Revenue forecast for 2011 is$350 to 400 million.[2]

In 2010, Dendreon achieved FDA approval for its flagship therapy, Provenge, to treat advanced prostate cancer.[3] Revenue from sales of Provenge drove Dendreon's revenue increase in 2010, and will continue to drive Dendreon's revenue as it continues to build market share. Dendreon has yet to post a profit, and operational expenses to develop, manufacture, and market Provenge tripled to $300 million in 2010. Thomson Reuters projects an earnings loss again in 2011, but sees Dendreon becoming profitable in 2012.[4]

Pipeline

Provenge treats cancer as an active cellular immunotherapy (ACI), getting the patient's immune system to selectively attack cancer cells. Dendreon is developing the Provenge compound (Sepuleucel-T) as well as other ACI compounds for several cancer types[5]:

  • Sepuleucel-T: Dendreon currently has Sepuleucel-T, the compound behind Provenge, in Phase 2 and 3 trials for both early and advance stage Prostate cancer.
  • ACI Therapy for Breast Cancer: Dendron has a therapy that targets the Her2 receptor common in certain forms of breast cancer currently in Phase 1 trials.

Trends and Forces

Sales Growth for Provenge Will Drive Dendreon's Future Revenue

Over the next few years, virtually all of Dendreon's revenue will come from sales of its cancer drug, Provenge. Analysts predict that Provenge sales will peak at $2-3 billion, with sales in 2012 of $800 million.[6] However, the sales numbers that Dendreon is actually able to realize depend on a few factors. First, as the first cancer treatment of its kind, demand for Provenge may be difficult to predict. Second, Provenge costs $93,000 for 4 months of life extension in cancer patients, a cost that some doctors may balk at.[7] Dendreon's valuation over the next few years will be inextricably tied to the performance of Provenge.

Dendreon's Ability to Keep Up with Provenge Demand will Affect Revenue

The process of manufacturing Provenge is relatively complex, requiring treatments personalized for each patient, and Dendron may have trouble keeping up with demand. Early on, the company has seen production constraints dampen sales.[8][9] While Dendreon has added three manufacturing plants to its arsenal in order to meet demand,[10] the complexities inherent to the manufacturing process make manufacturing capacity an important indicator for Provenge's short-term sales.

Competition

Sanofi-Aventis SA (SNY): Sanofi Aventis received FDA approval for it new drug, Jevtana, to treat patients with advanced prostate cancer. Jevtana will compete with Provenge for patients, although the demand backlog for Provenge while Dendreon ramps up its capacity, will make up for any sales losses from competition.[11]

JOHNSON & JOHNSON (JNJ): Zytiga received FDA approval for advanced prostate cancer and will compete along with Provenge and Jevtana for market share.[12]

References

  1. DNDN 2011 10K
  2. BiotechSectorInvesting DNDN Earnings
  3. FDA Approves a Cellular Immunotherapy for Men with Advanced Prostate Cancer
  4. Ahead of Earnings: Analysts Fight Over Dendreon (DNDN)
  5. Dendreon R&D
  6. Dendreon: Make or Break Year for Provenge
  7. Provenge Cancer Vaccine: Can You Put a Price on Delaying Death?
  8. Dendreon's Biggest Provenge Problem? Managing Demand
  9. Dendreon sees Provenge contraints over by year end
  10. Dendreon boosts Provenge production, treatment sites
  11. New Dendreon Competition Is Not Really Competition (DNDN, SNY)
  12. Abiraterone in Prostate Cancer, Survival Gets Even Better
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