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This excerpt taken from the ELN 20-F filed Feb 26, 2009. Beta
Secretase
Beta secretase, sometimes called BACE (for Beta-site of APP
Cleaving Enzyme), is believed to initiate the first step in the
formation of beta amyloid, the precursor to plaque development
in the brain. Our findings concerning the role beta secretase
plays in beta amyloid production, published in Nature in
1999, are considered a landmark discovery. Today, we continue to
be at the center of understanding the complexities of beta
secretase. Our ongoing drug discovery efforts in this area focus
on inhibiting beta secretase and its role in the progression of
Alzheimer’s disease pathology.
This excerpt taken from the ELN 20-F filed Feb 28, 2008. Beta
Secretase
Beta secretase is believed to initiate the first step in the
formation of beta amyloid, the precursor to plaque development
in the brain. Our findings concerning the role beta secretase
plays in beta amyloid production, published in Nature in
1999, are considered a landmark discovery. Today, we continue to
be at the center of understanding the complexities of beta
secretase. Our ongoing preclinical drug discovery efforts in
this area focus on inhibiting beta secretase and its role in the
progression of Alzheimer’s disease pathology.
This excerpt taken from the ELN 20-F filed Feb 28, 2007. Beta
Secretase
Beta secretase is believed to initiate the first step in the
formation of beta amyloid, the precursor to plaque development
in the brain. We have been an industry leader in beta secretase
research for more than 10 years. Our findings concerning
the role beta secretase plays in beta amyloid production,
published in Nature in 1999, are considered a landmark
discovery. Today, we continue to be at the center of
understanding the complexities of beta secretase and advancing
agents that inhibit its role in Alzheimer’s disease
pathology. In 2005, we resolved our dispute with Pfizer Inc.
(Pfizer), our former collaborator on the beta secretase program.
The settlement allows for both companies to operate with freedom
in the beta secretase space. We are continuing our pre-clinical
drug discovery efforts, including expansion of our strategic
industry-leading patent portfolio covering beta secretase small
molecule inhibitors.
This excerpt taken from the ELN 20-F filed Mar 30, 2006. Beta
Secretase
Beta secretase is believed to initiate the first step in the
formation of beta amyloid, the precursor to plaque development
in the brain. We have been an industry leader in beta secretase
research for more than 10 years. Our findings concerning
the role beta secretase plays in beta amyloid production,
published in Nature in 1999, are considered a landmark
discovery. Today, we continue to be at the center of
understanding the complexities of beta secretase and advancing
potential disease-modifying agents that inhibit its role in
Alzheimer’s disease pathology. In 2005, we resolved our
dispute with Pfizer Inc. (Pfizer), our former collaborator on
the beta secretase program. The settlement allows for both
companies to operate with freedom in the beta secretase space.
We are aggressively continuing our preclinical drug discovery
efforts, including expansion of our strategic industry-leading
patent portfolio covering beta secretase small molecule
inhibitors.
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