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ELN » Topics » About NanoCrystal Technology

This excerpt taken from the ELN 20-F filed Feb 28, 2008.
NanoCrystal® Technology
 
EDT’s proprietary NanoCrystal technology is a drug optimization technology applicable to many poorly water-soluble compounds. It is an enabling technology for evaluating new chemical entities exhibiting poor water-solubility and a tool for optimizing the performance of established drugs. NanoCrystal technology involves reducing crystalline drugs to particles under 400 nanometers in size. By reducing particle size, the exposed surface area of the drug is increased and then stabilized to maintain particle size. The drug in NanoCrystal form can be incorporated into common dosage forms, including tablets, capsules, inhalation devices, and sterile forms for injection, with the potential for substantial improvements to clinical performance.
 
The potential benefits of applying the NanoCrystal technology for existing and new products include:
 
  •  Enhancing oral bioavailability;
 
  •  Increased therapeutic effectiveness;
 
  •  Reducing/eliminating fed/fasted variability;
 
  •  Optimizing delivery; and
 
  •  Increased absorption.
 
EDT’s NanoCrystal technology has now been incorporated into 4 commercialized products, with more than 30 other compounds at various stages of development.


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This excerpt taken from the ELN 20-F filed Mar 30, 2006.
About NanoCrystal Technology
 
NanoCrystal technology involves reducing crystalline drug to particles under 400 nanometers. By reducing particle size, the exposed surface area of the drug is increased and is then stabilized to maintain particle size. The drug in nano-form can be incorporated into common dosage forms, including tablets, capsules, inhalation devices, and sterile forms for injection, with the potential for substantial improvements to clinical performance.
 

EXCERPTS ON THIS PAGE:

20-F
Feb 28, 2008
20-F
Mar 30, 2006

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