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This excerpt taken from the ELN 20-F filed Feb 28, 2007. Parkinson’s
Research
Parkinson’s disease is believed to be a result of misfolded
proteins in the brain. Parkinson’s disease is characterized
by the accumulation of aggregated alpha-synuclein, or Lewy
bodies, in degenerating neurons in particular regions of the
brain.
Our early discovery efforts in Parkinson’s disease are
guided by our expertise and leadership in Alzheimer’s
disease research. We made significant scientific progress in
2006, identifying unusual modified forms of alpha-synuclein in
human Parkinson’s disease brain tissue. These unique forms
have led us to a series of therapeutic targets that will be a
focus of our small and large molecule drug discovery efforts
over the next few years.
Our scientists are also studying parkin, a protein found in the
brain that has been genetically linked to Parkinson’s
disease. Parkin may be involved in the elimination of misfolded
proteins within neurons. Some familial forms of Parkinson’s
disease have been linked to mutations in parkin, and we are
actively studying the relationship between parkin activity and
neurodegeneration. This research is in the drug discovery stage.
This excerpt taken from the ELN 20-F filed Mar 30, 2006. Parkinson’s
Research
Parkinson’s disease is believed to be a result of misfolded
proteins in the brain. Parkinson’s disease is characterized
by the accumulation of aggregated alpha-synuclein, or Lewy
bodies, in degenerating neurons in particular regions of the
brain.
Our early discovery efforts in Parkinson’s disease are
guided by our expertise and leadership in Alzheimer’s
disease research. We made significant scientific progress in
2005, identifying unusual modified forms of alpha-
Table of Contents
synuclein in human Parkinson’s disease brain tissue. These
unique forms have led us to a series of therapeutic targets that
will be a focus of our drug discovery efforts over the next few
years. Some of our findings were published in the June 2005
edition of the journal Neuron.
Our scientists are also studying parkin, a protein found in the
brain that has been genetically linked to Parkinson’s
disease. Parkin may be involved in the elimination of misfolded
proteins within neurons. Some familial forms of Parkinson’s
disease have been linked to mutations in parkin, and we are
actively studying the relationship between parkin activity and
neurodegeneration. This research is in the drug discovery stage.
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