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ELN » Topics » Our Secretase Inhibitor Research

This excerpt taken from the ELN 20-F filed Feb 28, 2007.
Our Secretase Inhibitor Research
 
Beta and gamma secretases are proteases (enzymes that break down other proteins) that appear to clip the APP, resulting in the formation of beta amyloid. This is significant because if the “clipping” of APP could be prevented, the pathology of Alzheimer’s disease may be changed. We have been at the forefront of research in this area, publishing extensively since 1989, and have developed and are pursuing advanced discovery programs focused on molecule inhibitors of beta and gamma secretases.
 
This excerpt taken from the ELN 20-F filed Mar 30, 2006.
Our Secretase Inhibitor Research
 
Beta and gamma secretases are proteases (enzymes that break down other proteins) that appear to clip the APP, resulting in the formation of beta amyloid. This is significant because if the “clipping” of APP could be prevented, the pathology of Alzheimer’s disease may be changed. As a result of these discoveries, we have developed and are pursuing advanced discovery programs focused on molecule inhibitors of beta and gamma secretases. We have been at the forefront of research in this area, publishing extensively since 1989, and anticipate moving small molecule secretase antagonists into the clinic in the next two to three years.
 

EXCERPTS ON THIS PAGE:

20-F
Feb 28, 2007
20-F
Mar 30, 2006

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