QUOTE AND NEWS
Market Intelligence Center  May 12  Comment 
Monday’s trading in Incyte (INCY) gives options traders an opportunity for a 13.33% return. By selling the Sep. '15 $100.00 call and buying the Jan. '16 call at the $57.50 level for a net debit of $37.50, traders will book a profit as long as...
Market Intelligence Center  May 1  Comment 
The patented option-trade picking algorithms that power MarketIntelligenceCenter.com's Artificial Intelligence Center  are highlighting two trades on Incyte (INCY) today after it closed at $97.16 on Thursday. For more conservative investors, look...
newratings.com  Apr 30  Comment 
WASHINGTON (dpa-AFX) - Biopharmaceutical company Incyte Corp. (INCY) reported a net loss of $18.36 million or $0.11 per share for the first quarter, narrower than $33.96 million or $0.21 per share a year ago. On average, 13 analysts polled by...
Market Intelligence Center  Apr 30  Comment 
Incyte (INCY) was selected by MarketIntelligenceCenter.com’s trade-picking algorithms today after trading between $98.04 and $102.24 on Wednesday before closing at $101.67. A diagonal spread using a long position in the Jan. '16 $45.00 call and...
Benzinga  Apr 17  Comment 
Incyte Corporation (Nasdaq: INCY) today announced that eleven abstracts detailing its emerging development pipeline will be presented at the 2015 American Association for Cancer Research (AACR) Annual Meeting in Philadelphia, PA. These...
FierceBiotech  Apr 14  Comment 
With close to two dozen clinical-stage programs underway and plans to add more, Incyte is moving to set up a research shop in Geneva, Switzerland, to oversee all of its R&D efforts on the continent.
Forbes  Apr 13  Comment 
In trading on Monday, the SPDR S&P Biotech ETF (XBI) is outperforming other ETFs, up about 1.8% on the day.  Components of that ETF showing particular strength include shares of Clovis Oncology (CLVS), up about 13.6% and shares of Incyte Genomics...
GenEng News  Apr 8  Comment 
Agenus said today it has acquired Celexion’s SECANT® Yeast Display Platform for generating monoclonal antibodies and other antibody-related assets. Agenus said the $4 million-plus asset deal will speed up its checkpoint inhibitor collaborations...
Market Intelligence Center  Apr 6  Comment 
Incyte (INCY) closed Thursday at $88.79 and technical indicators recently have been bullish. With those figures in place, the algorithms behind MarketIntelligenceCenter.com's Artificial Intelligence Center have identified a couple of attractive...




 

Incyte Corporation (NYSE: INCY) is a Wilmington, DE-based drug discovery and development company with a focus on oral compounds to treat HIV, inflammation, cancer, and diabetes. The company has transformed from a genomic-based information supplier to a fully integrated drug discovery and development organization. The company's lead internal compound, Ruxolitinib, has completed phase III clinical trials for the treatment of myelofibrosis and submitted an NDA application to the FDA in June of 2011.

The ability of Incyte to push its lead compounds through regulatory approval and to maintain the cash required to do so will impact Incyte Corporation's long-term success.

Business Growth[1]

In 2010, total revenues for Incyte were $170 million, reflecting milestone payments received from drug development partners. These milestone payments include $50 million from Novartis AG (NVS) for the initiation of the RESPONSE clincal trial, $49 million from Eli Lilly and Company (LLY) for two early stage drugs, and $67 million in amortized payments made earlier by the two partner companies.

Net loss for 2010 was $31.8 million, down from a 2009 net loss of $212 million.

Pipeline[2][3]

  • Ruxolitinib: Incyte's flagship product, Ruxolitinib is currently in two Phase III studies, COMFORT and RESPONSE to study its use as a treatment for myelofibrosis and polycythemia vera, two rare diseases without current approved treatments. The COMFORT trial has been completed and Incyte submitted an NDA application to the FDA in June of 2011.[4] The RESPONSE trial began in the fourth quarter of 2010. Ruxolitinib is also involved in Phase I and II trials to treat leukemia and other blood-based diseases.[5]
  • Sheddase Inhibitors: Incyte is developing INCB7839 to treat Her-2 positive breast cancer. Phase II trials have been completed and Incyte will decide whether to progress to Phase III trials.

Trends and Forces

Incyte Needs to Obtain Regulatory Approval in Order to Earn Significant Revenue

To date, all of Incyte's revenue has been earned from milestone payments paid by pharmaceutical partners for the development of its flagship product, Ruxolitinib. In order to make the full transition from a development-stage company to a fully commercial pharmaceutical company, Incyte needs to obtain regulatory approval for its drugs. Incyte submitted an NDA application for the use of Ruxolitinib to treat myelofibrosis in 2011 and will receive a response from the FDA in late 2012 or early 2013. The outcome of that response will profoundly impact Incyte's valuation.[6]

Cash on Hand will Impact Incyte's Ability to Maintain Operations

In the absence of organic revenue, Incyte is reliant on its cash on hand to fund ongoing operations. As of the end of 2010, Incyte had $418 million in cash.[7] In 2011, Incyte expects to cash use to range between $185 and $200 million.[8] Incyte's ability to maintain positive cash as it develops its lead products will impact its ability to bring these drugs to market and develop a revenue stream of its own.

Competition

Ruxolitinib belongs to a class of drugs called Jak inhibitors. The following companies are developing drugs within this class:

  • YM BioSciences (YMI): Developing a Jak inhibitor for myelofibrosis that could be a direct competitor to Ruxolitinib. YM BioSciences' drug is in Phase II clinical trials.[9]
  • Sanofi-Aventis SA (SNY): In 2010, Sanofi-Aventis purchased TargeGen, whose flagship drug is a Jak inhibitor being developed to treat myelofibrosis.[10]

References

  1. Incyte Reports 2010 Financial Results; Provides 2011 Key Objectives And Financial Guidance
  2. INCY 2011 10K
  3. Incyte Product Pipeline
  4. Incyte Submits NDA For Ruxolitinib For Rare Blood Cancer
  5. Incyte Corporation's CEO Discusses Q1 2011 Results- Earnings Call Transcript
  6. Incyte Corporation's CEO Discusses Q1 2011 Results- Earnings Call Transcript
  7. INCY 2011 10K
  8. Incyte Reports 2010 Financial Results; Provides 2011 Key Objectives And Financial Guidance
  9. Incyte and YM Biosciences in Race to Market Strongest JAK Inhibitor
  10. On a spree, Sanofi scoops up TargeGen in $635M Deal
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