ISIS » Topics » DOCUMENTS INCORPORATED BY REFERENCE

These excerpts taken from the ISIS 10-K filed Feb 26, 2009.

DOCUMENTS INCORPORATED BY REFERENCE

 

(To the extent indicated herein)

 

Portions of the Registrant’s definitive Proxy Statement for the fiscal year ended December 31, 2008 to be filed on or about April 6, 2009 with the Securities and Exchange Commission in connection with the Registrant’s annual meeting of stockholders to be held on June 2, 2009 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 63 to 66 incorporates several documents by reference as indicated therein.

 


*                                         Excludes 27,845,955 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2008. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.

 

 

 



DOCUMENTS INCORPORATED BY REFERENCE

 

(To the extent indicated herein)

 

Portions of the Registrant’s definitive Proxy Statement for the fiscal year ended December 31, 2008 to be filed on or about April 6, 2009 with the Securities and Exchange Commission in connection with the Registrant’s annual meeting of stockholders to be held on June 2, 2009 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 63 to 66 incorporates several documents by reference as indicated therein.

 


*                                         Excludes 27,845,955 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2008. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.

 

 

 



DOCUMENTS INCORPORATED BY REFERENCE



 



(To the extent
indicated herein)



 



Portions of
the Registrant’s definitive Proxy Statement for the fiscal year ended December 31,
2008 to be filed on or about April 6, 2009 with the Securities and
Exchange Commission in connection with the Registrant’s annual meeting of
stockholders to be held on June 2, 2009 are incorporated by reference into
Part III of this Report. The Exhibit Index (Item No. 15) located
on pages 63 to 66 incorporates several documents by reference as indicated
therein.



 






*                                         Excludes
27,845,955 shares of common stock held by directors and officers and by
stockholders whose beneficial ownership is known by the Registrant to exceed
10% of the common stock outstanding at June 30, 2008. Exclusion of shares
held by any person should not be construed to indicate that such person
possesses the power, direct or indirect, to direct or cause the direction of
the management or policies of the Registrant, or that such person is controlled
by or under common control with the Registrant.



 





 





 














DOCUMENTS INCORPORATED BY REFERENCE



 



(To the extent
indicated herein)



 



Portions of
the Registrant’s definitive Proxy Statement for the fiscal year ended December 31,
2008 to be filed on or about April 6, 2009 with the Securities and
Exchange Commission in connection with the Registrant’s annual meeting of
stockholders to be held on June 2, 2009 are incorporated by reference into
Part III of this Report. The Exhibit Index (Item No. 15) located
on pages 63 to 66 incorporates several documents by reference as indicated
therein.



 






*                                         Excludes
27,845,955 shares of common stock held by directors and officers and by
stockholders whose beneficial ownership is known by the Registrant to exceed
10% of the common stock outstanding at June 30, 2008. Exclusion of shares
held by any person should not be construed to indicate that such person
possesses the power, direct or indirect, to direct or cause the direction of
the management or policies of the Registrant, or that such person is controlled
by or under common control with the Registrant.



 





 





 














DOCUMENTS INCORPORATED BY REFERENCE



 



(To the extent
indicated herein)



 



Portions of
the Registrant’s definitive Proxy Statement for the fiscal year ended December 31,
2008 to be filed on or about April 6, 2009 with the Securities and
Exchange Commission in connection with the Registrant’s annual meeting of
stockholders to be held on June 2, 2009 are incorporated by reference into
Part III of this Report. The Exhibit Index (Item No. 15) located
on pages 63 to 66 incorporates several documents by reference as indicated
therein.



 






*                                         Excludes
27,845,955 shares of common stock held by directors and officers and by
stockholders whose beneficial ownership is known by the Registrant to exceed
10% of the common stock outstanding at June 30, 2008. Exclusion of shares
held by any person should not be construed to indicate that such person
possesses the power, direct or indirect, to direct or cause the direction of
the management or policies of the Registrant, or that such person is controlled
by or under common control with the Registrant.



 





 





 














These excerpts taken from the ISIS 10-K filed Mar 13, 2008.

DOCUMENTS INCORPORATED BY REFERENCE

(To the extent indicated herein)

         Portions of the Registrant's definitive Proxy Statement for the fiscal year ended December 31, 2007 to be filed on or about April 18, 2008 with the Securities and Exchange Commission in connection with the Registrant's annual meeting of stockholders to be held on June 4, 2008 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 87 to 92 incorporates several documents by reference as indicated therein.


*
Excludes 12,057,915 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2007. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.





FORWARD-LOOKING STATEMENTS

        This report on Form 10-K and the information incorporated herein by reference includes forward-looking statements regarding our business, the therapeutic and commercial potential of our technologies and products in development, and the financial position of Isis Pharmaceuticals, Inc., our Ibis Biosciences subsidiary and our Regulus Therapeutics joint venture. Any statement describing our goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should be considered an at-risk statement, including those statements that are described as Isis' goals or projections. Such statements are subject to certain risks and uncertainties, particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, in developing and commercializing systems to identify infectious organisms that are effective and commercially attractive, and in the endeavor of building a business around such products. Our forward-looking statements also involve assumptions that, if they never materialize or prove correct, could cause our results to differ materially from those expressed or implied by such forward looking statements. Factors that could cause or contribute to such differences include, but are not limited to, those discussed in this report on Form 10-K, including those identified in Item 1A entitled "Risk Factors". Although our forward-looking statements reflect the good faith judgment of our management, these statements are based only on facts and factors currently known by us. As a result, you are cautioned not to rely on these forward-looking statements.


TRADEMARKS

DOCUMENTS INCORPORATED BY REFERENCE



(To the extent indicated herein)



         Portions
of the Registrant's definitive Proxy Statement for the fiscal year ended December 31, 2007 to be filed on or about April 18, 2008 with the Securities and Exchange
Commission in connection with the Registrant's annual meeting of stockholders to be held on June 4, 2008 are incorporated by reference into Part III of this Report. The Exhibit Index
(Item No. 15) located on pages 87 to 92 incorporates several documents by reference as indicated therein.






*
Excludes
12,057,915 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock
outstanding at June 30, 2007. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the
direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.




noshade width=100% align=left size=1>























NAME="da78901_forward-looking_statements">


FORWARD-LOOKING STATEMENTS



        This report on Form 10-K and the information incorporated herein by reference includes forward-looking statements
regarding our business, the therapeutic and commercial potential of our technologies and products in development, and the financial position of Isis Pharmaceuticals, Inc., our Ibis Biosciences
subsidiary and our Regulus Therapeutics joint venture. Any statement describing our goals, expectations, financial or other projections, intentions or beliefs is a forward-looking statement and should
be considered an at-risk statement, including those statements that are described as Isis' goals or projections. Such statements are subject to certain risks and uncertainties,
particularly those inherent in the process of discovering, developing and commercializing drugs that are safe and effective for use as human therapeutics, in developing and commercializing systems to
identify infectious organisms that are effective and commercially attractive, and in the endeavor of building a business around such products. Our forward-looking statements also involve assumptions
that, if they never materialize or prove correct, could cause our results to differ materially from those expressed or implied by such forward looking statements. Factors that could cause or
contribute to such differences include, but are not limited to, those discussed in this report on Form 10-K, including those identified in Item 1A entitled "Risk Factors".
Although our forward-looking statements reflect the good faith judgment of our management, these statements are based only on facts and factors currently known by us. As a result, you are cautioned
not to rely on these forward-looking statements.



NAME="da78901_trademarks">


TRADEMARKS




This excerpt taken from the ISIS 10-K filed Mar 16, 2007.

DOCUMENTS INCORPORATED BY REFERENCE

(To the extent indicated herein)

Portions of the Registrant’s definitive Proxy Statement for the fiscal year ended December 31, 2006 to be filed on or about April 5, 2007 with the Securities and Exchange Commission in connection with the Registrant’s annual meeting of stockholders to be held on May 17, 2007 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 83 to 88 incorporates several documents by reference as indicated therein.


* Excludes 11,628,302 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2006. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.

 




This excerpt taken from the ISIS 10-K filed Aug 9, 2006.

DOCUMENTS INCORPORATED BY REFERENCE

(To the extent indicated herein)

Portions of the registrant’s definitive Proxy Statement to be filed on or about March 22, 2006 with the Securities and Exchange Commission in connection with Registrant’s annual meeting of stockholders to ber held on May 3, 2006 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 72 to 77 incorporates several documents by reference as indicated therein.


*                    Excludes 13,007,479 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2005. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.

 


 

This excerpt taken from the ISIS 10-K filed Mar 16, 2006.

DOCUMENTS INCORPORATED BY REFERENCE

(To the extent indicated herein)

Portions of the registrant’s definitive Proxy Statement to be filed on or about March 22, 2006 with the Securities and Exchange Commission in connection with Registrant’s annual meeting of stockholders to be held on May 3, 2006 are incorporated by reference into Part III of this Report. The Exhibit Index (Item No. 15) located on pages 72 to 77 incorporates several documents by reference as indicated therein.


*                     Excludes 13,007,479 shares of common stock held by directors and officers and by stockholders whose beneficial ownership is known by the Registrant to exceed 10% of the common stock outstanding at June 30, 2005. Exclusion of shares held by any person should not be construed to indicate that such person possesses the power, direct or indirect, to direct or cause the direction of the management or policies of the Registrant, or that such person is controlled by or under common control with the Registrant.

 




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