This excerpt taken from the ISIS DEF 14A filed Apr 4, 2007.
Option Exercises in Fiscal 2006(1)
(1) The Company currently does not utilize stock awards as part of its compensation plan. As such, the Company does not include information regarding stock awards that would otherwise appear as blank columns in this table.
(2) All exercises and resulting sales were made pursuant to the Named Executive Officers Rule 10b5-1 trading plan.
(3) Exercise of transferred stock options by Ms. Parshalls two daughters pursuant to Ms. Parshalls Rule 10b5-1 trading plan.