newratings.com  Jun 3  Comment 
SUMMIT (dpa-AFX) - Shares of Achaogen Inc. (AKAO) rose nearly 13% on Thursday, following a $20 million contract option awarded by BARDA to support the development of the company's lead product candidate Plazomicin. Plazomicin is under a...
Globe Newswire  Oct 29  Comment 
DALLAS, Oct. 29, 2009 (GLOBE NEWSWIRE) -- StockPreacher.com announces an investment report featuring Metabasis Therapeutics (Nasdaq:MBRX). The report includes financial and investment analysis, analyst consensus, and pertinent industry information
FierceBiotech  Oct 27  Comment 
Less than two months after its CEO announced plans to jump ship, Ligand Pharmaceuticals announced a deal to buy the struggling La Jolla, CA-based Metabasis (MBRX) for only $3.2 million in cash--less net liabilities--and contingency value rights...
FierceBiotech  Sep 2  Comment 
The CEO of Metabasis Therapeutics, Mark Erion, is leaving his post to join Merck as vice president and head of its worldwide franchise for obesity and diabetes. Metabasis has been struggling to garner enough cash to keep its doors open....
StreetInsider.com  Jun 10  Comment 
Visit StreetInsider.com at http://www.streetinsider.com/Corporate+News/Metabasis+%28MBRX%29+To+Receive+%246M+Fee+From+Merck%2C+But+Still+Warns+About+Its+Future/4722746.html for the full story.


Metabasis Therapeutics, Inc. is a biopharmaceutical company that engages in the discovery and development of drugs for chronic diseases involving pathways in the liver. The company provides products primarily for metabolic diseases, such as diabetes, hyperlipidemia, and liver diseases, including hepatitis and liver cancer. The company's pipeline candidates include MB07133 (for the treatment of primary liver cancer), MB07803 (for the treatment of type-II diabetes), and MB07811 (for the management of hyperlipidemia), all of which are in early-to-mid stages of clinical development. Metabasis received disappointing news in July 2007 related to the clinical development of two mid-stage candidates - CS-917 (for the treatment of type-II diabetes) and pradefovir (for the treatment of hepatitis B). While CS-917 failed to achieve the primary endpoint in a phase IIb trial, results from toxicology studies for pradefovir showed a higher dose-related incidence of cancer. The pradefovir news resulted in the termination of the company's development and commercialization agreement with Schering-Plough. As far as CS-917 is concerned, Metabasis announced that it will not continue with the development of the candidate.

Metabasis Therapeutics has strategic alliances with several larger pharmaceutical companies, including Valeant Pharmaceuticals, Daiichi Sankyo Co., Ltd., and Merck & Co. These collaborations helped Metabasis generate $4.4 million in revenues in 2006. Metabasis Therapeutics, Inc. is based in La Jolla, California.


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