MBRX » Topics » MB07133

This excerpt taken from the MBRX 10-K filed Mar 13, 2007.

MB07133

Cytarabine, or araC, is a marketed anti-cancer drug used to treat leukemia. AraC has shown only limited success in solid tumors such as primary liver cancer because the liver lacks a particular protein, or kinase, necessary for converting it to an important intermediate form known as araCMP.  MB07133 uses our HepDirect technology to deliver this intermediate form of araC to the liver where it is then readily converted by a different liver kinase into its anti-cancer form, known as araCTP. This approach bypasses the need for the first kinase which the liver lacks. In addition, araC, when systemically delivered is readily converted to araCTP in tissues such as the bone marrow where it can cause toxicity. MB07133 appears to

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avoid this potential toxicity because the HepDirect prodrug version of araCMP is not converted to araCTP in tissues outside the liver. We believe the unique ability of MB07133 to deliver araCMP selectively to the liver where it can be readily converted into its anti-cancer form will enhance efficacy while minimizing the toxicities associated with systemic araC therapy.

This excerpt taken from the MBRX 8-K filed Mar 8, 2007.

MB07133

The Phase 1/2 dose escalation clinical trial of MB07133, a HepDirect oncolytic being studied as a treatment for hepatocellular carcinoma (HCC) or primary liver cancer, was completed during 2006 and preliminary results were presented at the 2006 American Society of Clinical Oncology (ASCO) meeting.  These results showed that MB07133 at doses up to 2400mg/m2/day IV infusion was well tolerated in patients with unresectable HCC and that there were no clinically significant dose-limiting toxicities associated with the therapy. Although this study was not designed to demonstrate the efficacy of MB07133, encouraging signs of drug activity were observed, including evidence of disease stabilization and tumor shrinkage in some patients who received multiple cycles of the product candidate. With completion of the trial, a maximal dose of 2400mg/m2/day was selected for further study.  The next clinical trial is expected to begin later in 2007.

This excerpt taken from the MBRX 10-K filed Mar 23, 2006.

MB07133

 

MB07133 uses our HepDirect technology to target the active form of araC to the liver while decreasing levels of the active form of the drug in tissues outside of the liver. AraC is a marketed anti cancer drug used to treat leukemia. AraC is effective against leukemia but not solid tumors, including primary liver cancer, in large part because the enzymes required for conversion of araC to araCTP exist predominantly in leukemic cells and bone marrow cells. Conversion of araC to araCTP in bone marrow results in the dose-limiting toxicity that is traditionally associated with araC therapy.

 

Using our HepDirect technology, we developed MB07133, a product candidate that produces higher levels of araCTP in the liver with little to no araCTP produced in the bone marrow. MB07133 causes higher levels of araCTP in the liver because it effectively bypasses the first step in the metabolic pathway used to convert araC to araCTP, which otherwise requires an enzyme that is present only at relatively low levels in the liver. At the same time, MB07133 produces low levels of araCTP in the bone marrow because it is not readily converted to araCTP in bone marrow and blood. We believe that this change in distribution of araCTP will maximize MB07133’s potential therapeutic effect on liver tumors while minimizing its toxicity.

 

This excerpt taken from the MBRX 10-K filed Mar 31, 2005.

MB07133

        MB07133 is a HepDirect prodrug of araC, a well known off-patent oncolytic drug used for the treatment of leukemia. AraC is effective against leukemia but not solid tumors, including primary liver cancer, in large part because the enzymes required for conversion of araC to araCTP exist predominantly in leukemic cells and bone marrow cells. Conversion of araC to araCTP in bone marrow results in the dose-limiting toxicity that is traditionally associated with araC therapy.

        Using our HepDirect technology, we developed MB07133, a drug compound that results in higher levels of araCTP in the liver with little to no araCTP produced in the bone marrow. MB07133 causes higher levels of araCTP in the liver because it effectively bypasses the first step in the metabolic pathway used to convert araC to araCTP, which otherwise requires an enzyme that is present only at relatively low levels in the liver. At the same time, MB07133 produces low levels of araCTP in the bone marrow because it is not readily converted to araCTP in bone marrow and blood. We believe that this

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change in distribution of araCTP will maximize MB07133's potential therapeutic effect on liver tumors while minimizing its toxicity.

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