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This excerpt taken from the NVS 6-K filed Feb 19, 2010. About Ph+ CML
CML is a disease in which the body produces cancerous white blood cells. Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl. Bcr-Abl causes malignant white blood cells to proliferate(4). Worldwide, CML is responsible for approximately 10 to 15% of all adult cases of leukemia(5), with an incidence of one to two cases per 100,000 people per year(6).
This excerpt taken from the NVS 6-K filed Dec 10, 2009. About Ph+ CML CML is a disease in which the body produces cancerous white blood cells. Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl. Bcr-Abl causes malignant white blood cells to proliferate(6). Worldwide, CML is responsible for approximately 10% to 15% of all adult cases of leukemia(7), with an incidence of one to two cases per 100,000 people per year(8).
This excerpt taken from the NVS 6-K filed Oct 21, 2009. About Ph+ CML CML is a disease in which the body produces cancerous white blood cells. Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl. Bcr-Abl causes malignant white blood cells to proliferate(3). Worldwide, CML is responsible for approximately 10 to 15% of all adult cases of leukemia(10), with an incidence of one to two cases per 100,000 people per year(11).
This excerpt taken from the NVS 6-K filed Jun 5, 2009. About Ph+ CML
CML is a disease of the blood and bone marrow in which the body produces cancerous white blood cells. Almost all patients with CML have an abnormality known as the Philadelphia chromosome, which produces a protein called Bcr-Abl. Bcr-Abl causes malignant white blood cells to proliferate(7). Worldwide, CML is responsible for approximately 15% of all adult cases of leukemia(8), with an incidence of one to two cases per 100,000 people per year(9).
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