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This excerpt taken from the SNY 6-K filed Sep 30, 2009. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years. It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed. At the same time, about 40 percent of those diagnosed are not achieving the blood sugar control target of HbA1c <7 percent recommended by the ADA. The HbA1c test measures average blood glucose levels over the past two- to three-month period. These excerpts taken from the SNY 6-K filed Jul 29, 2009. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years. It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed. At the same time, approximately 40 percent of those diagnosed are not achieving the blood sugar control target of HbA1c <7 percent recommended by the ADA. The HbA1c test measures average blood glucose levels over the past two- to three-month period. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years. It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed. At the same time, approximately 40 percent of those diagnosed are not achieving the blood sugar control target of HbA1c <7 percent recommended by the ADA. The HbA1c test measures average blood glucose levels over the past two- to three-month period. This excerpt taken from the SNY 6-K filed Jun 29, 2009. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years. It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed. At the same time, approximately 40 percent of those diagnosed are not achieving the blood sugar control target of HbA1c <7 percent recommended by the ADA. The HbA1c test measures average blood glucose levels over the past two- to three-month period. This excerpt taken from the SNY 6-K filed Feb 27, 2009. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. More than 230 million people worldwide are living with the disease and this number is expected to rise to a staggering 350 million within 20 years.iii It is estimated that nearly 24 million Americans have diabetes, including an estimated 5.7 million who remain undiagnosed.iv At the same time, approximately 40 percent of those diagnosed are not achieving the blood sugar control target of A1C <7 percent recommended by the ADA.v The A1C test measures average blood glucose levels over the past two- to three-month period. This excerpt taken from the SNY 6-K filed Oct 31, 2008. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to transport glucose (sugar) from the blood into the cells of the body for energy. In type 1 diabetes, the immune system destroys the insulin-producing beta cells of the pancreas that regulate blood glucose. Since the pancreas can no longer produce insulin, people with type 1 diabetes require daily injections of insulin for their entire lives. The International Diabetes Foundation estimates the global number of children 14 years of age and younger with type 1 diabetes to be 440,000, with 70,000 newly diagnosed cases each year. In the United States, type 1 diabetes is the most common type of diabetes in children, with approximately 176,500 people under 20 years of age affected by the disease. Approximately one out of every 400 to 600 American children and adolescents has type 1 diabetes. This excerpt taken from the SNY 6-K filed Sep 11, 2008. About Diabetes Diabetes is a chronic, progressive widespread disease in which the body reduces or does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. In 2008 over 250 million people worldwide are living with diabetes. This number would dramatically increase up to 380 million by 2025. It is estimated more than 24 million Americans have diabetes. At the same time, more than 40% of those diagnosed are not achieving the general blood sugar control standard of A1C <7% recommended by the American Diabetes Association and the European Association for the Study of Diabetes (ADA/EASD). The A1C test reflects average blood glucose levels over a two- to three-month period. Without proper insulin production and action, glucose remains in the blood, leading to chronic hyperglycaemia (raised blood sugar). This can result in short and long-term complications, many of which, if not prevented and left untreated, can be fatal. All have the potential to reduce the quality of life of people with diabetes and their families. The most common long-term complications are:
Diabetes is the fourth leading cause of death by disease globally. Every year, 3.8 million people die from diabetes-related causes.
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This excerpt taken from the SNY 6-K filed Jul 21, 2008. About Diabetes Diabetes is a chronic, progressive widespread disease in which the body reduces or does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. More than 240 million people worldwide are living with the disease. At the same time, more than 40% of patients are not achieving the general blood sugar control standard of A1C <7% recommended by the
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American Diabetes Association and the European Association for the Study of Diabetes (ADA/EASD). The A1C test reflects average blood glucose levels over a two- to three-month period. These excerpts taken from the SNY 6-K filed Jun 9, 2008. About Diabetes Diabetes is a chronic, progressive widespread disease in which the body reduces or does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. More than 240 million people worldwide are living with the disease. It is estimated that near 250 million people worldwide have diabetes, the number is expected to reach some 380 million within 20 years. It is estimated more than 20 million Americans have diabetes, including an estimated 6.2 million who remain undiagnosed. At the same time, approximately half of those diagnosed are not achieving the general blood sugar control standard of A1C <7% recommended by the American Diabetes Association and the European Association for the Study of Diabetes (ADA/EASD). The A1C test reflects average blood glucose levels over a two- to three-month period. Without proper insulin production and action, glucose remains in the blood, leading to chronic hyperglycaemia (raised blood sugar). This can result in short and long-term complications, many of which, if not prevented and left untreated, can be fatal. All have the potential to reduce the quality of life of people with diabetes and their families. The most common long-term complications are:
Diabetes is the fourth leading cause of death by disease globally. Every year, 3.8 million people die from diabetes-related causes. About Diabetes Diabetes is a chronic, progressive widespread disease in which the body reduces or does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. More than 240 million people worldwide are living with the disease. It is estimated that near 250 million people worldwide have diabetes, the number is expected to reach some 380 million within 20 years. It is estimated more than 20 million Americans have diabetes, including an estimated 6.2 million who remain undiagnosed. At the same time, more than 40% of those diagnosed are not achieving the general blood sugar control standard of A1C <7% recommended by the American Diabetes Association and the European Association for the Study of Diabetes (ADA/EASD). The A1C test reflects average blood glucose levels over a two- to three-month period. Without proper insulin production and action, glucose remains in the blood, leading to chronic hyperglycaemia (raised blood sugar). This can result in short and long-term complications, many of which, if not prevented and left untreated, can be fatal. All have the potential to reduce the quality of life of people with diabetes and their families. The most common long-term complications are:
Diabetes is the fourth leading cause of death by disease globally. Every year, 3.8 million people die from diabetes-related causes.
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This excerpt taken from the SNY 6-K filed Sep 18, 2007. Diabetes: The prevalence of diabetes is increasing worldwide and the number of diabetics could reach 330 million by 2025, compared with 194 million in 2003. Meanwhile, it is estimated that only about one-third of patients are adequately controlled with current available treatments. Our portfolio targets all stages of the disease while offering relevant solutions for concomitant comorbidities, in particular overweight.
The new development program in diabetes, essentially as an add-on on top of the main existing treatments (metformin, sulfonylurea and insulin), includes a comparative study with sitagliptin, the most recently approved treatment:
In addition, the program also includes a first-line monotherapy study versus placebo (SOLO), a study in the prevention of type 2 diabetes (RAPSODI, enrolment completed), and a study of a fixed rimonabant/ metformin combination. Submission in type 2 diabetes is expected in 2009, while submission of a fixed rimonabant/metformin combination is expected in 2010. Results from the ADAGIO study, evaluating rimonabant in patients with dyslipidemia, will be presented at the Congress of the European Atherosclerosis Society in April 2008. We expect to submit a fixed combination of rimonabant plus a statin in 2011. Enrolment of patients to the CRESCENDO morbidity/mortality study is ongoing and on target, with around 11,000 out of the planned 17,000 already enrolled. The results of this study are expected in 2011, and we expect to file for approval by the healthcare authorities in the same year. A major development program for rimonabant is also under way in Japan. Three phase III studies are ongoing, and should result in filing for approval in Japan in 2009:
We are also planning to submit in the rest of Asia (including China) during 2008 on the basis of the positive results of the RIO-ASIA study.
By associating or combining these products, it should be possible to meet all the needs of diabetic patients whatever the stage of the disease.
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This excerpt taken from the SNY 6-K filed May 2, 2007. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. More than 230 million people worldwide are living with the disease. This number is expected to rise to a staggering 350 million within 20 years.2 It is estimated more than 20 million Americans have diabetes, including an estimated 6.2 million who remain undiagnosed.3 At the same time, approximately half of those diagnosed are not achieving the general blood sugar control standard of A1C <7% recommended by the American Diabetes Association (ADA).4 The A1C test measures average blood glucose levels over a two- to three-month period.
This excerpt taken from the SNY 6-K filed Mar 26, 2007. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin – the hormone needed to convert glucose (sugar) into energy. More than 230 million people worldwide are living with the disease. This number is expected to rise to a staggering 350 million within 20 years. It is estimated that more than 20 million Americans have diabetes, including an estimated 6.2 million who remain undiagnosed1. At the same time, approximately half of those diagnosed are not achieving the general blood sugar control standard of A1C <7% recommended by the American Diabetes Association (ADA)2. The A1C test measures average blood glucose levels over a two- to three-month period. This excerpt taken from the SNY 6-K filed Jun 21, 2006. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce or properly use insulin, the hormone needed to convert glucose (sugar) into energy. It is estimated that more than 20 million Americans have diabetes, including 6.2 million who remain undiagnosed. At the same time, approximately half of those diagnosed are not achieving the general blood sugar control standard of HbA1c<7% recommended by the American Diabetes Association (ADA). The HbA1ctest measures blood glucose levels over a two - to three-month period. This excerpt taken from the SNY 6-K filed Mar 1, 2006. About Diabetes Diabetes is a chronic, widespread condition in which the body does not produce, or properly use insulin, the hormone needed to convert glucose (sugar) into energy. People with diabetes may need different types of insulin at certain times of the day and at different stages of the progression of their diabetes to help them manage their blood glucose levels. Optimal treatment of hyperglycemia closely mimics the patient’s physiology. Controlling blood sugar levels is an important key to fighting the current diabetes epidemic. In the U.S., more than 20 million people have diabetes, including an estimated 6 million who remain undiagnosed. At the same time, approximately 60 percent of those diagnosed are not in control. According to the American Diabetes Association, the optimal control goal for people with diabetes in general is an A1C level of less than 7 percent. The A1C test measures blood glucose levels over a two- to three-month period. The United Kingdom Prospective Diabetes Study (UKPDS) showed that using insulin in the treatment of type 2 diabetes can – when combined with oral medications, diet, and exercise – help people with diabetes achieve and maintain tight glucose control, helping to reduce their risk of blindness, amputation, kidney failure, stroke and heart attack.
This excerpt taken from the SNY 6-K filed Jan 26, 2005. Diabetes Lantus® 2004 net sales of Lantus® were 843 million euros, up 79.7% . Net sales rose by 57.2% in the United States (to 495 million euros) and by 111.4% in Europe (to 295 million euros). In 2004, Lantus® became the best-selling insulin brand in the United States, reaching 24.5%11 of total insulin prescriptions. In the fourth quarter, net sales of Lantus® advanced by 35.9% in the United States (to 131 million euros) and by 63.3% in Europe (to 88 million euros). Amaryl®2004 net sales of Amaryl® were up 18.8% at 684 million euros. Net sales growth was 32.0% in the United States (to 216 million euros) and 9.0% in Europe (to 239 million euros). Amaryl® posted fourth-quarter net sales growth of 42.2% in the United States (to 62 million euros), thanks to increased prescriptions and a favorable price effect. In Europe, net sales rose by 7.9% (to 66 million euros). | EXCERPTS ON THIS PAGE:RELATED TOPICS for SNY:
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