Zetia and Vytorin are hugely successful cholesterol drugs with novel action mechanisms and sales approaching $4 billion in 2006. Recent Japanese approval of the treatments means increased sales, and with no additional testing and trials necessary, a high proportion of sales is profit.
Schering-Plough is working with Johnson & Johnson on a possible successor to its most successful drug, Remicade. The autoimmune treatment market is growing, and so any advances in this field would be very profitable.