TPTX » Topics » Its the Underlying Cause, Not Just the Symptoms

This excerpt taken from the TPTX 8-K filed Sep 28, 2006.

It’s the Underlying Cause, Not Just the Symptoms

from the March-April
2006 edition*…

Triptans only address the vascular component

New paradigm - migraine is a progressive neurological disorder

Tezampanel and NGX426 target the underlying neurological changes

in other words…

“The newer theory is that migraine is a neurovascular
disorder,” Lipton says. The perpetrator may be the brain
itself--not the blood vessels, he says.

Managing Migraines by L. Bren; quote Richard Lipton MD

11


This excerpt taken from the TPTX DEFA14A filed Sep 28, 2006.

It’s the Underlying Cause, Not Just the Symptoms

from the March-April
2006 edition*…

Triptans only address the vascular component

New paradigm - migraine is a progressive neurological disorder

Tezampanel and NGX426 target the underlying neurological changes

in other words…

“The newer theory is that migraine is a neurovascular
disorder,” Lipton says. The perpetrator may be the brain
itself--not the blood vessels, he says.

Managing Migraines by L. Bren; quote Richard Lipton MD

11


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